2024年4月10日 · Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a gamma herpes virus that occurs only in humans. Laboratory testing can help distinguish whether someone is susceptible to EBV infection or has a recent or past infection. EBV antibody tests are not usually needed to diagnose infectious mononucleosis.

Epstein-Barr nuclear antigen 1 (EBNA1) was the first Epstein-Barr virus (EBV) protein detected and is the most widely studied [1]. EBNA1 is expressed in both latent and lytic modes of EBV infection, although it has mainly been studied in latency, where it plays multiple important roles.

2023年7月12日 · EBV nuclear antigen (EBNA). You develop antibodies to EBNA 2 to 4 months after infection, and they last for the rest of your life. They are not present during the acute phase of infection.

Epstein–Barr nuclear antigen 1 (EBNA1) is a multifunctional, dimeric viral protein associated with Epstein–Barr virus (EBV). [1] It is the only EBV protein found in all EBV-related malignancies. [2] [3] It is important in establishing and maintaining the …

2019年6月11日 · The EBV (Epstein Barr) Nuclear Antigen Antibodies, IgG test looks for a type of antibody which the body typically develops in response to Epstein-Barr Virus. EBNA antibodies usually appear 2-4 months after infection and persist for the life of the person.

Nuclear antigen 1 (EBNA-1) is one of the key functions of the oncogenic DNA virus, Epstein-Barr virus (EBV), and is the only viral protein consistently expressed in EBV-associated malignancies. EBNA-1 binds in a site-specific manner to the viral DNA and is essential for viral replication, as well as for maintaining the genome as an ...

2018年2月20日 · The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B cell transformation is poorly defined, but it has been reported to enhance gene activation by the EBV protein EBNA2 in vi …

2019年9月11日 · The EBV nuclear antigen (EBNA)-1 induces the accumulation of reactive oxygen species (ROS), which enables B-cell immortalization but causes oxidative DNA damage and triggers...

The presence of the Epstein-Barr virus (EBV)-encoded nuclear antigen-1 (EBNA1) protein in all EBV-carrying tumours constitutes a marker that distinguishes the virus-associated cancer cells from normal cells and thereby offers opportunities for ...

EBNA-2是主要的病毒反激活因子，参与潜伏病毒转录的调控，并有助于EBV感染细胞的永生化。 典型的EBV基因组包含三种这样的蛋白:EBNA-3A (EBNA-3)， EBNA-3B (EBNA-4)， EBNA-3C (EBNA-6)。 这些基因也结合宿主RBP-Jκ蛋白。 在病毒粒子包膜表面形成刺突的包膜糖蛋白。 参与病毒和细胞膜的融合导致病毒进入宿主细胞。 异二聚体糖蛋白h -糖蛋白L是病毒和质膜融合导致病毒进入宿主细胞所必需的。 在与宿主整合素结合后，gL与gH分离，导致病毒融合糖蛋白gB …