2024年12月24日 · ECE1 (Endothelin Converting Enzyme 1) is a Protein Coding gene. Diseases associated with ECE1 include Hirschsprung Disease, Cardiac Defects, And Autonomic Dysfunction and Hypertension, Essential. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene. [5][6][7] Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides. [5] ^ "Human PubMed Reference:".

Endosomal endothelin-converting enzyme-1 is a regulator of beta-arrestin-dependent ERK signaling By degrading endocytosed SP, ECE-1 promotes the recycling and re-sensitization of NK(1) receptors in endothelial cells, and thereby induces …

1994年8月12日 · We report the identification of ECE-1, a novel membrane-bound neutral metalloprotease that is expressed abundantly in endothelial cells in vivo and is structurally related to neutral endopeptidase 24.11 and Kell blood group protein.

2006年6月8日 · HGNC Approved Gene Symbol: ECE1. Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1; 131240), -2 (EDN2; 131241), and -3 (EDN3; 131242) to biologically active peptides.

2023年10月28日 · Endothelin converting enzyme 1 (ECE1) is a membrane-bound metalloprotease involved in endothelin-1 (ET-1) processing and regulates vasoconstriction. However, very few studies have reported the involvement of ECE1 in regulating tumor cell proliferation, and the mechanism remains poorly understood.

Title: Endothelin-converting enzyme-1 regulates glucagon-like peptide-1 receptor signalling and resensitisation. ECE-1 and ECE-2 levels were significantly reduced in post-mortem brains from dementia with Lewy body patients.

2024年9月12日 · Endothelin-converting enzyme-1c promotes stem cell traits and aggressiveness in colorectal cancer cells. Effects of ECE-1b rs213045 and rs2038089 polymorphisms on the development of contrast-induced acute kidney injury in patients with acute coronary syndrome.

2014年1月31日 · Endothelin-converting enzyme-1 (ECE-1) is the enzyme predominantly responsible for producing active endothelin-1 (ET-1), a mitogenic peptide implicated in the aetiology of a number of diseases, including cancer.

Endothelin-converting enzyme 1 (EC 3.4.24.71, endothelin-converting enzyme, ECE-1) is an enzyme. [1] [2] [3] This enzyme catalyses the following chemical reaction. Hydrolysis of the -Trp 21-Val- bond in big endothelin to form endothelin 1. This metalloendopeptidase belongs to the peptidase family M13.