2024年12月24日 · EED (Embryonic Ectoderm Development) is a Protein Coding gene. Diseases associated with EED include Cohen-Gibson Syndrome and Prc-2 Complex-Related Overgrowth Spectrum. Among its related pathways are RNA Polymerase I Promoter Opening and PIP3 activates AKT signaling.

Polycomb protein EED is a protein that in humans is encoded by the EED gene. [5][6][7] Polycomb protein EED is a member of the Polycomb -group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations.

2014年1月24日 · Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic...

2024年11月2日 · Gene target information for EED - embryonic ectoderm development (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

2019年4月11日 · EED-related overgrowth is characterized by fetal or early childhood overgrowth (tall stature, macrocephaly, large hands and feet, and advanced bone age) and intellectual disability that ranges from mild to severe. To date, EED-related overgrowth has been reported in eight individuals.

Embryonic Ectoderm Development (EED) as a Novel Target for Cancer Treatment. Methylation of microRNA-338-5p by EED promotes METTL3-mediated translation of oncogene CDCP1 in gastric cancer. PICOT binding to chromatin-associated EED negatively regulates cyclin D2 expression by increasing H3K27me3 at the CCND2 gene promoter.

2022年4月28日 · Here, we show that microglial EED is essential for synaptic pruning during the postnatal stage of brain development. The absence of microglial EED at early postnatal stages resulted in reduced...

2019年7月9日 · EED (embryonic ectoderm development) is a core component of the Polycomb repressive complex 2 (PRC2) which catalyzes the methylation of histone H3 lysine 27 (H3K27) during the process of self-renewal, proliferation, and differentiation of embryonic stem cells. However, its function in the mammalian nervous system remains unexplored.

2012年6月1日 · Polycomb recessive complex 2 (PRC2) is an epigenetic regulator that marks repressive chromatin domain through trimethylation of histone H3 lysine 27 (H3K27). 1, 2 Recently,...

Gene/transcipt that contains an open reading frame (ORF). Protein coding. A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest …