Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene. It is the archaeal and eukaryotic counterpart of bacterial EF-G. [5] [6] [7] [8] This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis.

2024年12月24日 · EEF2 (Eukaryotic Translation Elongation Factor 2) is a Protein Coding gene. Diseases associated with EEF2 include Spinocerebellar Ataxia 26 and Diphtheria. Among its related pathways are Peptide chain elongation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include RNA binding and protein kinase binding.

真核延伸因子2（英語： Eukaryotic elongation factor 2 ，eEF2）是一种蛋白质，由人类基因 EEF2 编码。 [1] [2] 这个基因编码的蛋白质是GTP结合翻译延伸因子家族的一员。这种蛋白质是蛋白质合成过程的一个重要组成部分，它促进GTP依赖的核糖体易位。

原核生物的移位需要延伸因子g（ ef-g ），真核中是eef2。ef-g与核糖体相互作用，以稳定其中间状态。核糖体结合可激活ef-g的gtp酶活性，利用gtp水解推动移位过程中的构象变化。 当前的翻译延伸模型是综合多种研究方法而得到的。

该蛋白被 EF-2 激酶磷酸化完全灭活。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.

The important component of eEFs, i.e. eEF2 promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. Mostly the eEF2 is regulated by phosphorylation and dephosphorylation by a specific kinase known as eEF2 kinase, which itself is up-regulated by various mechanisms in the eukaryotic cell.

2024年12月20日 · Eukaryotic elongation factor 2 (eEF2) is an essential regulator of protein synthesis that precisely elongates nascent peptides in the protein elongation process. Although studies have linked aberrant eEF2 expression to various cancers, research has primarily focused on its structure, highlighting a need for deeper exploration into its molecular ...

High serum eukaryotic elongation factor 2 level is associated with non-small cell lung cancer. Results indicated that the eEF2 gene is overexpressed in the majority of several types of cancers and plays an oncogenic role in cancer cell growth.

2022年5月10日 · Eukaryotic elongation factor-2 (eEF2), encoded by EEF2 gene that localizes on chromosome 19 in humans and a monomeric protein of 858 amino acid residues, is a key regulator of protein synthesis. 9 eEF2 belongs to the G protein family, and undergoes conformational changes upon binding to a guanosine nucleotide. 10 …

2021年9月15日 · Here, we show that the phosphorylation status of eukaryotic elongation factor-2 (eEF2) rapidly changes in response to synaptic and neural activities. Intraperitoneal injections of the GABA A receptor (GABAAR) antagonist picrotoxin and the glycine receptor antagonist brucine rapidly dephosphorylated eEF2.