2023年12月16日 · Epithelial sodium channel (ENaC) are integral to maintaining salt and water homeostasis in various biological tissues, including the kidney, lung, and colon. They enable …

2021年1月25日 · ENaC (epithelial sodium channel) is one of the key transporters responsible for the reabsorption of sodium in the distal nephron. This channel has an important role in the …

2015年12月15日 · Amiloride-sensitive epithelial sodium (Na +) channels (ENaCs) play a crucial role in Na + transport and fluid reabsorption in the kidney, lung, and colon. ENaC is made up …

The epithelial sodium channel (ENaC) is the rate-limiting step for sodium reabsorption across tight epithelia. Cyclic-AMP (cAMP) stimulation promotes ENaC trafficking to the apical surface to …

Control of hypertension and correction of hypokalemia can be achieved with the administration of large doses of ENaC blockers (amiloride or triamterene) but not with aldosterone receptor …

2020年1月7日 · ENaCs are activated by specific proteases in the biosynthetic pathway and at the cell surface and remove embedded inhibitory tracts, which allows channels to transition to …

2023年3月1日 · The epithelial Na + channel (ENaC) is a Na + selective and non–voltage-gated channel blocked by low concentrations of amiloride. ENaC expression has been detected on …

2018年9月25日 · The epithelial sodium channel (ENaC), a member of the ENaC/DEG superfamily, regulates Na + and water homeostasis. ENaCs assemble as heterotrimeric …

2021年12月9日 · The epithelial sodium channel (ENaC) plays a key role in salt and water homeostasis in tetrapod vertebrates. There are four ENaC subunits (α, β, γ, δ), forming …

The ENaC 2 has evolved as a channel that is thought to reside primarily in an active state, facilitating the bulk movement of Na + out of renal tubular or airway lumens. The regulated …