Egr-1 and HIF-1α siRNA were transiently transfected into breast cancer cells to evaluate their specific roles. Results: The increased Egr-1 expression occurring in hypoxic breast cancer cells can up-regulate TF expression and stimulating protein 1 (Sp1) was not responsible for the hypoxia-induced expression of TF.

2024年12月24日 · EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include Myelodysplastic Syndrome and Ischemia. Among its related pathways are PIP3 activates AKT signaling and Hepatocyte growth factor receptor signaling.

2023年11月17日 · EGR1 is essential for monopoiesis and binds enhancers that regulate monocytic developmental genes such as CSF1R. However, differentiating macrophages present a very different EGR1 binding pattern. We identify novel binding sites of EGR1 at a large set of inflammatory enhancers, even in the absence of its binding motif.

摘要： Egr-1（earlygrowthresponsivegene-1，Egr-1）是重要的核转录因子，其编码多种蛋白，在调控细胞的生长、分化、发育、增殖、炎性反应等方面发挥重要作用，本文针对其基因结构及特点，生物学特性、与肿瘤、炎症及肝损伤的关系作一简要综述。

According to our previous data, EGR-1 is decisively involved in the VEGF-mediated upregulation of TF, since deletion of the EGR-1 sites from the TF promoter abrogates VEGF-mediated induction of TF reporter genes (6, 7) and an adenovirus overexpressing the specific corepressor of EGR-1, NAB-2, strongly inhibited the VEGF effect on TF mRNA (5).

2013年2月14日 · The TF promoter contains three overlapping early growth response gene-1 (Egr-1)/stimulating protein 1 (Sp1)-binding sites within a proximal enhancer region (2111 to +14 bp) [4].

2000年3月1日 · Oxygen deprivation causes expression of Egr-1 in mononuclear phagocytes and vascular smooth muscle cells thereby activating downstream target genes such as TF. Expression of TF in hypoxemic/ischemic vasculature provides a mechanism triggering the procoagulant pathway and, potentially, resulting in fibrin deposition.

2021年1月13日 · EGR1 is essential for monopoiesis and binds enhancers that regulate monocytic developmental genes such as CSF1R. However, differentiating macrophages present a very different EGR1 binding pattern. We identify novel binding sites of EGR1 at a large set of inflammatory enhancers, even in the absence of its binding motif.

Tissue factor (TF) has been shown to be up-regulated in endothelial cells by the inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) as well as by the main angiogenic factor VEGF. Since both stimuli induce the transcription factor EGR-1, …

VEGF activated transcription factor Egr-1 within 60 min. Inactivation of Egr-1 by PD98059 resulted in the prohibition of VEGF-induced TF gene expression. EMSA revealed the increment of Egr-1 binding with TF promoter region by displacing Sp1 after treatment with VEGF.