2024年12月24日 · EIF2B1 (Eukaryotic Translation Initiation Factor 2B Subunit Alpha) is a Protein Coding gene. Diseases associated with EIF2B1 include Leukoencephalopathy With Vanishing White Matter 1 and Leukoencephalopathy With Vanishing White Matter 5. Among its related pathways are Peptide chain elongation and Translation Insulin regulation of translation.

Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the EIF2B1 gene. [5]

eIF2B is a protein complex found in eukaryotes. It is the guanine nucleotide exchange factor for the eukaryotic initiation factor 2 and therefore converts the inactive eIF2- GDP to the active eIF2- GTP.

2025年1月4日 · Clinical resource with information about EIF2B1, Leukoencephalopathy with vanishing white matter 1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Our results establish de novo EIF2B1 mutations as a novel cause of permanent diabetes and liver dysfunction. These findings confirm the importance of cell stress regulation for beta-cells and highlight EIF2B1's fundamental role within this pathway.

The EIF2B1 gene provides instructions for making one of five parts of a protein called eIF2B, specifically the alpha subunit of this protein. The eIF2B protein helps regulate overall protein production (synthesis) in the cell by interacting with another protein, eIF2.

该基因编码真核翻译起始因子 2B (EIF2B) 的五个亚基之一，真核翻译起始因子 2 的 GTP 交换因子和蛋白质合成的重要调节因子。 该基因和编码其他 EIF2B 亚基的基因的突变与白质消失的白质脑病有关。 [RefSeq 提供，2009 年 10 月] This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis.

eIF2B（eukaryotic initiation factor 2B， 真核起始因子 2B）是一种参与 真核翻译 起始的重要的 蛋白质，也是一种 鸟苷酸交换因子。 其作用是在翻译起始过程中，将 eIF2 上结合的 GDP （eIF2·GDP，eIF2的非活性状态）转换为 GTP （eIF2·GTP，eIF2的活性状态），使得eIF2可以重新参与翻译起始。 因此，在 细胞 中，eIF2B的作用是使足量的eIF2·GTP存在以参与翻译起始过程。 eIF2B是一种多亚基 复合物，包含五个 亚基，分别为α、β、γ、δ和ε。 eIF2B是与细胞生 …

真核起始因子2B（eukaryotic initiation factor 2B，简称eIF2B）是一种 鸟苷酸交换因子，也是一种参与真核翻译起始的重要的蛋白质。 其作用是在翻译起始过程中，将eIF2上结合的GDP（eIF2·GDP，eIF2的非活性状态）转换为GTP（eIF2·GTP，eIF2的活性状态），使得eIF2可以重新参与翻译起始。 因此，在细胞中，eIF2B的作用是使足量的eIF2·GTP存在以参与翻译起始过程。 eIF2B是一种多亚基复合物，包含五个亚基，分别为α、β、γ、δ和ε。 eIF2B是与细胞生 …

Gene ID: 209354, updated on 8-Feb-2025. This gene encodes the alpha subunit of the eukaryotic translation initiation factor complex 2B (eIF2B). The eIF2B complex is a heterodecamer comprised of two molecules each of alpha, beta, gamma, delta and epsilon subunits.