
EIF2S1 Gene - GeneCards | IF2A Protein | IF2A Antibody
2024年12月24日 · EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha) is a Protein Coding gene. Diseases associated with EIF2S1 include Vaccinia and Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus.
EIF2S1 - Wikipedia
Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene. [5][6]
真核翻译起始因子 2 亚基 alpha(EIF2S1)基因 | MCE
EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM ...
EIF2S1 eukaryotic translation initiation factor 2 subunit alpha
EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM ...
<br>EIF2S1(真核翻译起始因子 2 亚基 α)的磷酸化对于 ER 应激 …
eif2s1/eif2α 的磷酸化是一种重要机制,可以通过转录和翻译重编程调节所有三种 upr 途径,以维持细胞稳态并克服细胞应激。 在本研究中,为了研究 EIF2S1 磷酸化在 ER 应激期间自噬调节中的作用,我们使用了 EIF2S1 磷酸化缺陷 ( A/A ) 细胞,其中残基 51 从丝氨酸 ...
Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha ...
2025年2月8日 · In acute liver injury, inhibiting eIF2alpha (EIF2s1) dephosphorylation protects injured hepatocytes and reduces hepatocyte proliferation. TorsinA was post-transcriptionally upregulated upon acute ER stress, suggesting a role in this response.
eIF2 调控 | Cell Signaling Technology
eIF2 起始复合体整合了各种各样应激相关的信号来调控全局和特异性 mRNA 翻译。 在适宜的条件下,eIF2 会结合 GTP 和 Met-tRNAi 形成三元复合体 (TC),三元复合体随后结合 40S 核糖体亚基、eIF1、eIF1A、eIF5 和 eIF3,形成 43S 起始前复合体 (PIC)。 43S PIC 扫描 mRNA UTR 以寻找 AUG 起始密码子。 在识别 AUG 后,eIF2 在GTP酶活化蛋白 eIF5 的帮助下可将 GTP 水解为 GDP,并从 mRNA 上分解下来,以结合 60S 核糖体亚基并延长多肽链。 在 eIF5 作为 GDI 而 …
Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha ...
Predicted to enable ribosome binding activity and translation initiation factor activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of translational initiation in response to stress; and stress granule assembly.
EIF2S1人源基因|EIF2S1基因突变_致病性_靶点-RDDC官网
翻译起始因子EIF2是蛋白质合成起始的第一个受调控的步骤,促进起始tRNA与40S核糖体亚基的结合。 结合过程作为一个甲硫氨酸-tRNA、EIF2和GTP的三元复合物。 EIF2由3个不同的亚基组成,即36kD的EIF2-alpha亚基(EIF2S1),38kD的EIF2-beta亚基(EIF2S2;MIM 603908)和52kD的EIF2-gamma亚基(EIF2S3;MIM 300161)。 三元复合物的形成速度受EIF2-alpha磷酸化状态的影响(Ernst等人,1987年 [PubMed 2948954])。 [由OMIM于2010年2月提供] …
EIF2S1基因详情-基因数据库-基因云馆 - Genelibs
EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM ...