eif4a是dead盒rna解旋酶超家族成员，其氨基酸序列中具有8个保守区，保守区内含有一致的特殊序列。 已知的解旋酶结构具有两个结构域：rna结合结构域和atp酶结构域；保守区，包括atp结合位点，线性排列在两个结构域之间的裂缝中。 酵母的eif4a（缺少rna结合结构域）的n端atp酶结构域包含一个七个β链 ...

Eukaryotic initiation factor 4A-I (also known as eIF4A1 or DDX2A) is a 46 kDa cytosolic protein that, in humans, is encoded by the EIF4A1 gene, which is located on chromosome 17.

2024年12月24日 · EIF4A1 (Eukaryotic Translation Initiation Factor 4A1) is a Protein Coding gene. Diseases associated with EIF4A1 include Leukemia, Acute Myeloid and Hematologic Cancer. Among its related pathways are Peptide chain elongation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.

2024年11月8日 · This study demonstrates the distinct cellular and molecular functions of eIF4A1 and eIF4A2 and reveals a new role of eIF4A2 in controlling 40S ribosome biogenesis.

进一步研究证实参与真核翻译起始的一个重要atp依赖的rna解旋酶—真核翻译起始因子4a1 (eif4a1) 是usp9x的底物。 USP9X通过调控eIF4A1降解的速率从而调控了整体翻译的效率。

真核翻译起始因子 4a1： 启用双链 rna 结合活性。预计参与细胞质翻译起始。位于细胞质中。 [由基因组资源联盟提供，2022 年 4 月]

5 天之前 · eIF4A1 is the most abundant DEAD-box RNA helicase in HeLa and U2OS cells 29,32, with 5 to 50 eIF4A1 molecules per mRNA estimated 52. eIF4A1/2 is also present in a vast excess over the other ...

2024年5月21日 · Here we show that eIF4A1 enhances translational repression during the inhibition of mechanistic target of rapamycin complex 1 (mTORC1), an essential kinase complex controlling cell proliferation.

eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma. eIF4A/PDCD4 Pathway, a Factor for Doxorubicin Chemoresistance in a Triple-Negative Breast Cancer Cell Model. Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer.

While eIF4A1 controls global protein synthesis, eIF4A2 regulates the biogenesis of 18S ribosomal RNA and the 40S ribosome subunit. This study demonstrates the distinct cellular and molecular functions of eIF4A1 and eIF4A2 and reveals a new role of …