2024年12月24日 · EIF4EBP1 (Eukaryotic Translation Initiation Factor 4E Binding Protein 1) is a Protein Coding gene. Diseases associated with EIF4EBP1 include Tuberous Sclerosis and Rhabdomyosarcoma. Among its related pathways are Translation Insulin regulation of translation and Peptide chain elongation.

Eukaryotic translation initiation factor 4E-binding protein 1 (also known as 4E-BP1) is a protein that in humans is encoded by the EIF4EBP1 gene. [5] inhibits cap-dependent translation by binding to translation initiation factor eIF4E.

2024年12月24日 · EIF4EBP2 (Eukaryotic Translation Initiation Factor 4E Binding Protein 2) is a Protein Coding gene. Diseases associated with EIF4EBP2 include Fragile X Syndrome and Rett Syndrome. Among its related pathways are TGF-Beta Pathway and Beta-Adrenergic Signaling.

2024年12月24日 · This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure.

该基因编码翻译抑制蛋白家族的一个成员。 该蛋白质直接与真核翻译起始因子 4E (eIF4E) 相互作用，后者是将 40S 核糖体亚基募集到 mRNA 5' 端的多亚基复合物的限制成分。 这种蛋白质与 eIF4E 的相互作用会抑制复杂的装配并抑制翻译。 这种蛋白质响应于各种信号 (包括紫外线照射和胰岛素信号) 而被磷酸化，导致其与 eIF4E 解离并激活 mRNA 翻译。 [RefSeq 提供，2008 年 7 月] This gene encodes one member of a family of translation repressor proteins.

Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of a family of translation repressor proteins, and a well-known substrate of mechanistic target of rapamycin (mTOR) signaling pathway. Phosphorylation of 4E-BP1 causes its release from eIF4E to allow cap-dependent translation to proceed.

Tumoral EIF4EBP1 regulates the crosstalk between tumor-associated macrophages and tumor cells in MRTK. mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism.

This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1 ...

This study highlights how regulating T cell-intrinsic eIF4E activity can influence T cell activation and differentiation, suggesting the eIF4EBP-eIF4E axis as a potential therapeutic target for controlling aberrant T cell responses.

本综述探讨了EIF4EBP1基因在肿瘤研究中的进展,强调了其在多种肿瘤类型中的表达模式、功能作用以及作为潜在治疗靶点的重要性。 EIF4EBP1 ,作为mTOR信号通路的关键调控因子,参与调控蛋白质合成和细胞生长。 研究表明,EIF4EBP1在肾细胞癌、肝细胞癌、卵巢癌、子宫内膜癌和食管鳞癌等多种肿瘤中表现出不同的表达水平和生物学功能,其异常表达与肿瘤的发展和预后密切相关。 在信号通路方面,EIF4EBP1 与mTOR、AKT等通路的相互作用在肿瘤增殖、转移、凋亡逃逸和 …