2024年12月24日 · EIF4G2 (Eukaryotic Translation Initiation Factor 4 Gamma 2) is a Protein Coding gene. Diseases associated with EIF4G2 include Epilepsy, Idiopathic Generalized 4 and Mouth Disease. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Apoptotic Pathways in Synovial Fibroblasts.

The protein encoded by the eIF4G2 gene shares similarity with the C-terminal region of eIF4G1 that contains the binding sites for eIF4A and eIF3. eIF4G2 additionally contains a binding site for eIF4E at the N-terminus. Unlike eIF4G1, which supports cap-dependent and independent translation, the eIF4G2 gene product functions as a general ...

翻译起始是由真核翻译起始因子 4F (eIF4F) 对帽结构的特异性识别介导的，它是一种帽结合蛋白复合物，由三个亚基组成：eIF4A、eIF4E 和 eIF4G。 该基因编码的蛋白质与包含 eIF4A 和 eIF3 结合位点的 eIF4G 的 C 端区域具有相似性；此外，eIF4G 在 N 端包含一个 eIF4E 的结合位点。 与支持帽依赖性和独立翻译的 eIF4G 不同，该基因产物通过形成翻译失活复合物作为翻译的一般阻遏物。 体外和体内研究表明，这种 mRNA 的翻译完全从非 AUG (GUG) 密码子开始。 已经描述了 …

2024年4月8日 · These studies uncovered an unanticipated mechanism by which activity-dependent uORF translational control by eIF4G2 couples activity to local dendritic remodeling.

Eukaryotic translation initiation factor eIF4G2 opens novel paths for protein synthesis in development, apoptosis and cell differentiation. DAP5 drives translation of specific mRNA targets with upstream ORFs in human embryonic stem cells.

Here we show that the PCBP2 isoform f interacts with the 5'-UTRs of mRNAs encoding eIF4G2 (a translation initiation factor with a yet unknown mechanism of action, also known as DAP5) and Cyclin I, and inhibits their translation in vitro and in cultured cells, while the PCBP2 isoform e only affects Cyclin I translation.

2024年2月22日 · EIF4G2 depletion resulted in increased resistance to conventional therapies and increased the prevalence of molecular markers for aggressive cell subsets, altering their transcriptional...

2025年2月17日 · This eIF3d and eIF4G2 mediated form of translation is necessary for epithelial-mesenchymal transition (EMT), invasion, cell migration and metastasis (44). In this report, we provide the first quantitative and mechanistic insight into the utilization of eIF3d (the d-subunit of eIF3) as an alternative for the translation of specific mRNA subsets ...

2024年1月7日 · Clinical resource with information about EIF4G2, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Eukaryotic translation initiation factor 4G2 (eIF4G2, also called p97, NAT1 and DAP5), an eIF4G family member that lacks the binding sites for 5' cap binding protein eIF4E, is widely considered to be a key factor for internal ribosome entry sites (IRESs)-mediated cap-independent translation.