005628 B6.129S2- Emx1 tm1(cre)Krj /J Emx1-IRES-Cre knock-in mice have the endogenous Emx1 locus directing expression of Cre recombinase to approximately 88% of the neurons of the neocortex and hippocampus, and in the glial cells of the pallium.

将IRES-Cre插入到小鼠Emx1基因终止密码子处。 应用领域 ：Cre工具,88%的大脑皮层和海马神经元，大脑皮质神经胶质细胞等区域 *使用本品系发表的文献需注明: Emx1-IRES-Cre mice (Cat. NO. NM-KI-200149) were purchased from Shanghai Model Organisms Center, Inc..

Emx1-Cre. 用途：Emx1是大脑皮层和海马体发育中的一个重要转录因子。 应用： • 用于研究大脑皮层和海马体中的基因功能。 • 皮层神经元特异性基因敲除，研究大脑发育和功能。 Gorski, J. A., et al. (2002).

比如，受神经元特异性 Emx1（empty spiracles homolog 1）启动子驱动的 Cre 小鼠，除了在新皮质和海马中高表达 Cre 以外，在肾脏和胸腺中也会表达 Cre。 图1. Emx1-Cre在大脑（A）、胸腺（B）、肾脏（C）的表达。

2014年6月19日 · 目前已构建的 EMX1-cre 工具鼠中，Emx1. tm1(cre)Krj. 最常用，可在 Jackson Lab 直接购买。 Emx1. tm1(cre)Krj. 的活性表现在88%的大脑皮层及海马中的神经元细胞，与EMX1 的表达模式一. 致，cre 活性也表现在肾中。 小鼠名称 Jackson ID 原始文献 引用文献数 . Emx 1. t m1( cr e) Kr j

2002年8月1日 · By homologous recombination of an internal ribosome entry site and Cre recombinase coding region into the 3′-untranslated region of the mouse Emx1 gene, we have generated a strain of mice, Emx1 IREScre, that expresses the Cre recombinase in a spatial and temporal pattern like that observed for Emx1.

2000年7月5日 · We reported previously the creation of a line of transgenic mice in which the cre gene was placed directly downstream of the putative Emx1 promoter using ES cell technology. We showed that Cre protein was present in the cerebral cortex of the transgenic mice and was able to mediate loxP-specific recombination in vitro.

To assess the temporal and spatial speci®city of Cre-mediated recombination in Emx1-Cre mice, we crossed Emx1 Cre/Cre mice with ... ... homeobox gene, Emx1, which is expressed exclusively...

2020年7月31日 · To distinguish potential Ino80 functions in proliferating NPCs versus postmitotic neurons, we used two complementary Cre lines for Ino80 deletion. Emx1Cre mediates recombination in cortical...

The Emx1-IRES-Cre transgenic mouse is commonly used to direct genetic recombination in forebrain excitatory neurons. However, the original study reported that Emx1-Cre is also expressed embryonically in peripheral autonomic ganglia, which could ...