Homeobox protein engrailed-2 is a protein that in humans is encoded by the EN2 gene. [5] It is a member of the engrailed gene family.

2024年12月24日 · EN2 (Engrailed Homeobox 2) is a Protein Coding gene. Diseases associated with EN2 include Autism Spectrum Disorder and Alacrima, Achalasia, And Impaired Intellectual Development Syndrome . Among its related pathways is Dopaminergic neurogenesis .

Human genetic and mouse behavioral analyses suggest that ENGRAILED-2 (EN2) contributes to neurodevelopmental disorders, especially autism spectrum disorder. In mouse, En2 exhibits dynamic spatiotemporal expression in embryonic mid-hindbrain regions where monoamine neurons emerge.

2019年3月26日 · Engrailed-2 (EN2) is a homeodomain-containing transcription factor that has roles in boundary formation and neural guidance in early development, but which is also expressed in a...

2011年9月6日 · Our autism research has focused on the homeobox transcription factor, ENGRAILED 2 (EN2). Prior to the advent of genome wide association and re-sequencing analysis, we selected EN2 as a candidate gene due to neuroanatomical similarities observed between individuals with autism and mouse En2 mutants.

In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that …

We aimed to study and compare the phenotypes of three series of patients: (1) patients with encephalic structural anomalies (ESA) and abnormalities in the genomic (DNA) and/or transcriptomic (RNAm) of EN2 (EN2-g), (2) ESA patients having other gene mutations (OG-g), and (3) ESA patients free of these mutations (NM-g).

Engrailed-2 (EN-2) is a developmentally regulated homeobox gene that is essential for Purkinje cell maturation and normal cerebellar development and patterning. The mean EN2 levels in prostate cancer patients were 3.76-fold higher than those in …

Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.

EN2 is located in a linkage region with variable evidence for association with autism. For example, studies have found associations in the Chinese Han population as well as AGRE, NIMH and CPEA cohorts.