The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions (Na +). It is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ, [2] These subunits are encoded by four genes: SCNN1A, SCNN1B, SCNN1G, and SCNN1D.

The ENaC causes endothelium-dependent relaxation impairment in mice aorta through the ROS/COX-2-mediated SGK-1/Nedd4-2 signaling pathway; blocking the ENaC facilitates attenuation of hyperhomocysteinemia-induced cardiovascular system disease .

2022年3月21日 · In this review, we focus on a subclass of membrane‐bound and soluble proteases that are defined as channel‐activating proteases (CAPs), since they induce Na + ion transport through an autocrine mechanism when co‐expressed with the highly amiloride‐sensitive epithelial sodium channel (ENaC) in Xenopus oocytes. These experiments first ...

2018年1月1日 · ENaC is a constitutively active channel and allows the Na + transport from the extracellular fluid into the cytoplasm (Hanukoglu and Hanukoglu 2016). In the epithelial cells of kidney tubules or distal airways, the absorbed Na + ions are then usually pumped into the interstitial fluid across the basolateral membrane via Na + -K + -ATPase (Fig. 1 ).

Increased ENaC expression could cause stiffening in endothelia resulting in reduced availability of nitric oxide—a characteristic early sign of HTN . ENaC is an important regulator of vascular nanomechanics and a transducer of mechanical forces and so potentially influences the onset of endothelial dysfunction and HTN [ 21 , 24 , 25 ].

2021年6月1日 · The Epithelial Na + Channel, ENaC, comprised of 3 subunits (αβγ, or sometimes δβγENaC), plays a critical role in regulating salt and fluid homeostasis in the body. It regulates fluid reabsorption into the blood stream from the kidney to control blood volume and pressure, fluid absorption in the lung to control alveolar fluid clearance at ...

上皮钠离子通道（enac），又叫阿米洛利敏感钠离子通道 （aasc），是控制钠离子通过细胞膜的跨膜离子通道。 ENaCs主要位于肾脏、汗腺、肺以及结肠，功能是重吸收钠离子帮助维持盐和水的平衡稳态。

上皮 Na+ 通道 ENaC 由 3 个亚基（αβγ，或有时 δβγENaC）组成，在调节体内盐和液体的稳态中起关键作用。 它调节从肾脏到血流中的液体重吸收以控制血容量和压力，调节肺中的液体吸收以控制出生时肺泡液体的清除和终生维持正常气道表面液体，以及远端结肠 ...

Active transepithelial sodium (Na +) transport by alveolar epithelial cells (AEC) is a driving force for reabsorption of fluid from the alveolar space, a function which accounts for the ability of the lung to remove alveolar fluid at the time of birth and represents the main mechanism for alveolar oedema resolution (Basset et al 1987; Hummler et...

The epithelial Na+ channel (ENaC) transports Na+ across tight epithelia, including the distal nephron. Different paradigms of ENaC regulation include extrinsic and intrinsic factors that affect the expression, single-channel properties, and intracellular trafficking of the channel.