2018年9月24日 · Here, we demonstrate that Enah is upregulated in GC and associated with AJCC stage, depth of invasion and poor overall survival (OS). Knockdown of Enah inhibited GC cell proliferation and...

2022年1月25日 · We tested whether putative new ENAH interaction partners bound to full-length proteins in mammalian cells. We overexpressed GFP-tagged full-length ENAH with FLAG-tagged FHOD1, IFT52, or TJAP1 and used an anti-FLAG antibody …

2021年12月2日 · Here, we report the surprising observation that PCARE is ~100-fold specific for ENAH over paralogs VASP and EVL and can selectively bind ENAH and inhibit ENAH-dependent adhesion in cells. Specificity arises from a mechanism whereby PCARE stabilizes a conformation of the ENAH EVH1 domain that is inaccessible to family members VASP and EVL.

Enah protein was labeled in green and MHC was labeled in red. The Z-line and M-band are indicated within a sarcomere. ... anti-Xenopus Enah (obtained from Dr. Jeffrey Miller), anti-GFP (abcam), anti-MyHC (DSHB), anti-actin (Thermo), anti-α-actinin (Sigma-aldrich), anti-myomesin (DSHB), anti-α-tubulin (abcam), and anti-integrin β1 (DSHB) at a ...

2021年12月2日 · A peptide from PCARE achieves >100-fold binding specificity for the EVH1 domain of ENAH, a protein important for metastasis, using a conformational shift mechanism unavailable to ENAH's closely related paralogs VASP and EVL.

2024年12月24日 · Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts.

Enabled homolog (ENAH) is an actin-binding protein that implicated in multiple malignant tumors. High ENAH expression has been verified to be associated with poor prognosis in hepatocellular carcinoma (HCC). We aimed to reveal the role of ENAH in HCC and the potential mechanism.

2018年9月24日 · Here, we demonstrate that Enah is upregulated in GC and associated with AJCC stage, depth of invasion and poor overall survival (OS). Knockdown of Enah inhibited GC cell proliferation and metastasis and vice versa.

Here, we report the surprising observation that PCARE is ~100-fold specific for ENAH over paralogs VASP and EVL and can selectively bind ENAH and inhibit ENAH-dependent adhesion in cells.

enah 肌动蛋白调节因子： 该基因编码启用/血管扩张剂刺激的磷蛋白的成员。 该基因家族的成员参与基于肌动蛋白的运动。 这种蛋白质参与调节肌动蛋白丝的组装并调节细胞粘附和运动。