EndMT是指在多种刺激因素作用下，内皮细胞失去其原有特征并向间充质细胞进行转化（肌成纤维细胞、平滑肌细胞等）的过程，其结果是ECs在极性、形态和功能等方面发生重大变化。

酸性微环境诱导 人脐静脉内皮细胞 （HUVECs）上皮细胞间充质转化（EndMT） 数据就是观察到表型（a）---表型标志物检测（b，c）---功能（d），a和d也可以放一起为功能表型。

EndMT is a complex biological process in which endothelial cells lose their specific phenotype and progressively evolve into cells with a mesenchymal phenotype that includes a spindle-shaped elongated cell morphology, loss of cell-cell junctions and polarity, and the acquisition of cellular motility and invasive and contractile properties.

2020年5月28日 · Endothelial-to-mesenchymal transition (EndMT) involves the phenotypic conversion of endothelial-to-mesenchymal cells, and was first discovered in association with...

Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell undergoes a series of molecular events that lead to a change in phenotype toward a mesenchymal cell (e.g. myofibroblast, smooth muscle cell). EndMT plays a ...

The endothelial to mesenchymal transition (EndMT) is the process by which endothelial cells lose a portion of their cellular features and obtain certain characteristics of mesenchymal cells, including loss of tight junctions, increased motility, and increased secretion of …

2019年4月11日 · EndMT is an intricate cellular differentiation process whereby endothelial cells detach and migrate away from the endothelium and, to varying extents, decrease endothelial properties and acquire mesenchymal features.

2023年3月13日 · EndMT is a process characterized by the downregulation of endothelial-specific markers such as CD31 and the upregulation of mesenchymal markers such as a-SMA, and EndMT occurs in a broad...

2018年9月1日 · The endothelial to mesenchymal transition (EndMT) is the process by which endothelial cells lose a portion of their cellular features and obtain certain characteristics of mesenchymal cells, including loss of tight junctions, increased motility, and increased secretion of extracellular matrix proteins.

内皮间充质转化(EndMT)即内皮细胞在促成纤维刺激下可获得成纤维细胞样表型.EndMT不仅参与人体心脏正常发育,还参与诸多疾病的发生发展.本文就近年来EndMT发生机制及其相关疾病研究进展作一综述,以期为临床相关疾病治疗提供新靶点.