EP3 Prostanoid Receptor Isoforms Utilize Distinct Mechanisms …
Here we characterize the differential mechanisms of ERK 1/2 pathway activation by three human EP 3 receptor isoforms stably expressed in human embryonic kidney cells (HEK). We also …
EP(3) prostanoid receptor isoforms utilize distinct mechanisms …
Using immunoblot analysis we found that nM concentrations of PGE(2) strongly stimulated the phosphorylation of ERK 1/2 by the EP(3-II) and EP(3-III) isoforms; whereas, ERK 1/2 …
Prostaglandin E2 receptor 3 (EP3) signaling promotes ... - Springer
2020年6月1日 · As a specific G-protein coupled PGE2 receptor, EP3 is demonstrated as a negative prognosticator of cervical malignancy. Now, we aimed to investigate the pathological …
Mouse EP3 α, β, and γ Receptor Variants Reduce Tumor Cell …
In this study we provide evidence that expressing murine EP3 α, β, and γ receptor variants in tumor cells reduces to the same degree their tumorigenic potential in vivo. In addition, …
层层进击的磷酸化信号—MAPK通路解析 (下) - 知乎
活化的erk的靶点包括p90核糖体s6激酶(rsk)和细胞质磷脂酶a2（cpla2）。 ERK也会入核，磷酸化转录因子 Elk-1 (383位和389位的丝氨酸)。 通常只有一种高度活化的ERK1或ERK2存在于细 …
EP3 receptor antagonist L798,106 reduces proliferation and migration …
2019年7月29日 · In SK-BR-3, EP3 antagonism showed a significant decrease in Gi-protein levels, an increase in cAMP levels, and no significant change in p-ERK1/2 expression. Conclusion: …
EP3受体各亚型对肝癌Huh-7细胞生长和侵袭作用的研究
前列腺素E2 (Prostaglandin E2，PGE2)是一种炎性介质，对肿瘤细胞的生长与侵袭能力有显著的促进作用。 在肝细胞癌细胞中，PGE2与细胞膜上的四种EPR (E prostanoid … 展开v. 万方数据 …
EP抑制剂、激动剂、拮抗剂、激活剂、调节剂、基因 - MCE
cj-42794 (cj-042794) 是一种口服有效的选择性前列腺素e受体 4 (ep4) 拮抗剂，其 ic 50 值为 10 nm，其选择性是 ep1、ep2 和 ep3 的 200 倍。cj-42794 可用于胃溃疡的研究。
ERK：细胞外调节蛋白激酶及其信号通路
2025年2月14日 · ERK（Extracellular Regulated Protein Kinases）即细胞外调节蛋白激酶，包括ERK1和ERK2，是将信号从细胞表面受体传导至细胞核的关键激酶。 ERK1和ERK2的分子量 …
EP2 Induces p38 Phosphorylation via the Activation of Src in HEK …
The most significant increases in PGE 2-induced Erk phosphorylation were observed in EP1- and EP3-transfected cells, while PGE 2 treatment slightly increased Erk phosphorylation in EP2 …