2024年11月1日 · We generated sensory nerve EP4-specific knockout mice, with the genotype of Avil-CreEP4 fl/fl, was propagated. Transcriptome sequencing and bioinformatics analysis …

Avil −/ mice by crossing Advillin-cre mice with EP4wt mice to validate of EP4 function in sensory nerves. qPCR analysis and immunostaining of EP4 confirmed that EP4 deletion was …

2021年8月2日 · We have identified PGE2/EP4-mediated skeletal interoception, in which PGE2 secreted by osteoblasts activates EP4 in sensory nerves to induce phosphorylation of cAMP …

2024年3月5日 · To determine whether mechanical loading-induced bone formation is mediated by PGE2-EP4 signaling in sensory nerves, we generated sensory nerve-specific EP4 knockout …

2020年3月19日 · Here, we found that after sensory denervation, knockout of the EP4 receptor in sensory nerves, or knockout of COX-2 in osteoblasts, could significantly promote adipogenesis …

2022年1月27日 · EP4 expression in primary DRG neurons was increased more than 10-fold relative to treatment with Mg 2+ alone (Fig. 6a). We then generated EP4 Avil −/− mice by …

2024年11月5日 · Previous research has shown that sensory nerve prostaglandin E2 receptor 4 (EP4) signaling not only governs pain perception but also influences bone formation. However, …

2020年5月12日 · In our study, we investigated whether EP4-PGE2 in sensory nerves regulate bone mass 86 accrual through direct control of commitment of MSCs by tuning down …

To determine whether mechanical loading-induced bone formation is mediated by PGE2-EP4 signaling in sensory nerves, we generated sensory nerve-specific EP4 knockout mice (EP4 …

Here we report osteoblast secret prostaglandin E2 (PGE2) during aberrant subchondral bone remodeling induces pain and OA progression in mice. Specific deletion of the major PGE2 …