2011年4月24日 · Using a functional RNAi kinase screen, we identified epidermal growth factor receptor and ephrin receptor A2 as host cofactors for HCV entry. Blocking receptor kinase activity by approved...

Using a functional RNAi kinase screen, we identified epidermal growth factor receptor and ephrin receptor A2 as host cofactors for HCV entry. Blocking receptor kinase activity by approved inhibitors broadly impaired infection by all major HCV genotypes and viral escape variants in cell culture and in a human liver chimeric mouse model in vivo.

2024年12月25日 · ( EPHA2_HUMAN,P29317) (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.

2010年12月7日 · Using a functional RNAi kinase screen, we identified epidermal growth factor receptor and ephrin receptor A2 as host cofactors for HCV entry. Blocking receptor kinase activity by approved...

2012年12月1日 · This study identifies two receptor tyrosine kinases (EGFR and EphA2) as important for HCV entry. The data implicate the signaling pathways downstream of these receptors in coordinating interactions between CD81 and CLDN1. Licensed inhibitors of EGFR (erlotinib) and EphA2 (dasatinib) have antiviral activity both in vitro and in vivo.

2020年5月1日 · Using a functional RNA interference kinase screen, Lupberger et al. (2011) identified EGFR and EPHA2 as host cofactors for hepatitis C virus (HCV; see 609532) entry into cells. Clinically approved receptor tyrosine kinase (RTK) inhibitors (erlotinib and dasatinib) or RTK-specific antibodies impaired infection by all major HCV genotypes and ...

Using a functional RNAi kinase screen we identified epidermal growth factor receptor and ephrin receptor A2 as host co-factors for HCV entry. Blocking of kinase function by approved inhibitors broadly inhibited HCV infection of all major HCV genotypes and viral escape variants in cell culture and an animal model in vivo .

With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry.

Using a functional RNAi kinase screen we identified epidermal growth factor receptor and ephrin receptor A2 as host co-factors for HCV entry. Blocking of kinase function by approved inhibitors broadly inhibited HCV infection of all major HCV genotypes and viral escape variants in cell culture and an animal model in vivo.

2011年7月4日 · Epidermal growth factor receptor (EGFR) and ephrin receptor A2 (EphA2) have a key role in HCV entry, and inhibition of these host receptor tyrosine kinases (RTKs) could provide a viable new...