Ephrins (also known as ephrin ligands or Eph family receptor interacting proteins) are a family of proteins that serve as the ligands of the Eph receptor. Eph receptors in turn compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs).

Ephrins 可分为两大类，一种是通过 糖基磷脂酰肌醇 (GPI) 部分连接到细胞膜上的 ephrinAs (A1-A6)，另一种是跨越细胞膜并拥有细胞质信号域的 ephrinBs (B1-B3)。 在人类基因组中，共有9个 EphA 受体 和5个EphB受体。 EphA 受体混杂地结合5个Ephrin-A配体， EphB 受体 混杂地结合3个Ephrin-B配体。 Eph/Ephrin信号转导是双向的，在 Eph 受体表达细胞中称为正向信号转导，在 Ephrin 配体表达细胞中称为反向信号转导。 Eph/Ephrin信号通路在发育过程、成体组织稳态和 …

2023年11月23日 · 我提供了关于Eph受体-ephrin介导的细胞间通讯和细胞自主信号传导的不同机制的最新信息，以及Eph系统与其他信号系统的相互作用。 进一步讨论了最近在阐明Eph系统如何控制肿瘤扩张、侵袭性和转移、支持癌干细胞及驱动治疗抵抗方面的进展。 除了在癌细胞内部发挥作用外，Eph系统还介导癌细胞与肿瘤微环境中细胞之间的相互通讯。 Eph系统参与肿瘤血管生成的作用已得到充分证实，但最近的研究也显示其在免疫细胞、与癌症相关的成纤维细胞及细胞外 …

摘要: 促红细胞生成素肝细胞激酶 (Erythropoietin-producing hepatocellular, Eph)受体家族作为目前已知最大的酪氨酸激酶受体家族，通过受体–配体结合，介导人类从胚胎发育到成人组织稳态诸多生物学功能的调节，参与机体各种免疫反应。 研究发现，Eph受体在包括神经系统发育、细胞迁移、血管形成等许多生理发育过程中起重要作用，在调节免疫反应、肿瘤、炎症、损伤修复等病理过程中也发挥着重要功能。 进一步深入的研究Eph家族受体的生物学功能能够更好的对临床疾病 …

Ephrins 可分为两大类，一种是通过糖基磷脂酰肌醇 (GPI) 部分连接到细胞膜上的ephrinAs (A1-A6)，另一种是跨越细胞膜并拥有细胞质信号域的ephrinBs (B1-B3)。 Ephrins 及 Eph 受体均在细胞表面表达。 与其他受体酪氨酸激酶的配体不同，Ephrins 不能作为可溶性介质，而是必须通过膜结合来激活受体 (膜连接似乎可以聚集配体，而这种聚集是它们活动所必需的)。 Ephrins are a family of ligands that bind to the Eph receptors, the largest family of receptor tyrosine kinases.

2002年7月1日 · Biological functions for Eph receptors and ephrins include vascular development, tissue-border formation, cell migration, axon guidance and synaptic plasticity. Eph receptors can act as a ligand in...

2007年2月21日 · 双向信号传递是细胞间通讯领域中新近阐明的机制，酪氨酸激酶受体-配体 (Eph-ephrin) 介导的双向信号传递是此机制中的一个重要代表. Eph酪氨酸激酶家族受体及其配体ephrin家族成员是在神经发育、血管新生等方面起重要作用的分子，通过Eph向细胞内传递的信号称为正向信号，通过其配体ephrin的信号称为反向信号．Ephrin家族又可根据分子结构分为2个亚家族，其中ephrinB为跨膜蛋白，可通过酪氨酸磷酸化依赖和PDZ结合结构域介导2种方式向胞内 …

2017年2月6日 · In this Primer we will discuss some of the key aspects of signalling by Ephs and ephrins that make them pivotal players in health and disease. Eph receptors were first identified in 1987, during a screen for new oncogenic tyrosine kinases.

2016年1月21日 · Ephrin–Eph signalling regulates cell migration in neurons, allowing the cells to reach their final destination, guides axons along intermediate choice points to reach their final targets,...

EphrinA molecules, like many GPI-anchored proteins, are targeted to lipid rafts where they presumably assemble into protein complexes that transduce intracellular signals. Upon binding to its receptor, EphrinA and p75(NTR) colocalize within caveolae along retinal axons and form a complex that is required for Fyn phosphorylation, activating a ...

EphrinA/EphA-dependent axon repulsion is crucial for synaptic targeting in developing neurons but downstream molecular mechanisms remain obscure. Here, it is shown that ephrinA5/EphA3 triggers proteolysis of the neural cell adhesion molecule (NCAM) by the metalloprotease a disintegrin and metalloprotease (ADAM)10 to promote growth cone collapse ...

Increased expression of EphA2 and EphrinA-1 plays an important role in the progression human gastric adenocarcinoma. The crystal structures of an A-class complex between EphA2 and ephrin-A1 and of unbound EphA2, are presented.

Eph receptors and their ephrin ligands are important guidance molecules during neurological and vascular development. In recent years, it has become clear that the Eph protein family remains functional in adult physiology. A subset of Ephs and ephrins is …

2019年7月3日 · Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of essential processes in humans from embryonic development to adult tissue homeostasis through interactions with membrane-bound ephrin ligands.

2010年11月11日 · Eph receptor tyrosine kinases and their ephrin ligands are critical regulators of cell contact-dependent signaling and patterning. Eph/ephrin binding can lead to very diverse biological readouts such as adhesion versus repulsion, or increased versus decreased motility.

2024年11月12日 · Ephrin binding induces the formation of different types of Eph receptor oligomers on the cell surface. An emerging concept is that large clusters of tyrosine-phosphorylated receptors may seed cytoplasmic signaling complexes that resemble membraneless phase-separated condensates.

EphB4 and EphrinB2 are the Eph/Ephrin molecules that play essential roles in vascular development and postnatal angiogenesis. Analysis of expression patterns and function has linked EphB4/EphrinB2 to endothelial cell growth, survival, migration, assembly, and angiogenesis.

Conditioned media containing a soluble monomer of ephrinA1 caused EphA2 internalization and downregulation, dramatic alteration of cell morphology and suppression of the Ras–MAPK pathway. Moreover, soluble monomeric ephrinA1 was functional in a physiological context, eliciting collapse of embryonic neuronal growth cones.

2002年2月1日 · Engagement of Eph receptors by ephrin ligands mediates critical steps of angiogenesis, including juxtacrine cell–cell contacts, cell adhesion to extracellular matrix, and cell migration.

Erythropoietin-producing hepatocellular carcinoma A (EphA) receptors and their ephrin-A ligands are key players of developmental events shaping the mature organism. Their expression is mostly restricted to stem cell niches in adults but is reactivated in pathological conditions including lesions in the heart, lung, or nervous system.