Mechanistic insights into ER-associated protein degradation
Misfolded proteins of the endoplasmic reticulum (ER) are discarded by a conserved process, called ER-associated protein degradation (ERAD). ERAD substrates are retro-translocated …
Regulation of Endoplasmic Reticulum-Associated Protein …
Distinct endoplasmic reticulum-associated degradation (ERAD) pathways. Three main ERAD pathways in yeast are classified based on substrates and the components that are involved in …
Characterization of the Deubiquitinating Activity of USP19 and …
2014年2月7日 · Deubiquitinating enzymes (DUBs) regulate various cellular processes ranging from protein degradation to cellular signaling. USP19, the only DUB containing a carboxyl …
Cycles of autoubiquitination and deubiquitination regulate the ERAD …
2019年11月12日 · If the Hrd1 channel is activated by autoubiquitination, how is Hrd1 spared from degradation and returned to its inactive ground state? Here, we identify Ubp1 as a membrane …
Endoplasmic Reticulum Associated Protein Degradation (ERAD…
Ubiquitination in ERAD is also controlled by the opposing effect of deubiquitinases (DUB) that remove ubiquitin chains conjugated with ERAD substrates. DUBs were found to be in close …
Cellular functions regulated by deubiquitinating enzymes in ...
2021年8月1日 · DUBs function as modulators in a variety of neurodegenerative diseases. DUBs regulate toxic proteins inducing neurodegenerative diseases via proteasome signaling, …
去泛素化酶（DUB） - 知乎 - 知乎专栏
泛素一蛋白酶体途径 （ubiquitin-proteasome pathway）是细胞内一个重要的蛋白质降解调节系统。 通过对底物蛋白的多聚泛素化并经蛋白酶体降解，可以影响或调节多种细胞活动，包括： …
Regulation of Endoplasmic Reticulum-Associated Protein ... - MDPI
2014年6月6日 · DUBs remove single or multiple ubiquitins from polyubiquitin chains (PUCs), implying that PUCs on substrates are processed prior to their removal upon protein …
Characterization of the deubiquitinating activity of USP19 and its …
2014年2月7日 · Deubiquitinating enzymes (DUBs) regulate various cellular processes ranging from protein degradation to cellular signaling. USP19, the only DUB containing a carboxyl …
Roles of p97-associated deubiquitinases in protein quality control …
Surprisingly, recent studies have revealed an equally important function for deubiquitinases (DUBs), enzymes that disassemble ubiquitin chains, in ERAD. Intriguingly, many ERAD …