2012年3月9日 · Protein localization within cells regulates accessibility for interactions with co-factors and substrates. The endoplasmic reticulum (ER) BiP co-factor ERdj4 is up-regulated …

2012年3月9日 · Protein localization within cells regulates accessibility for interactions with co-factors and substrates. The endoplasmic reticulum (ER) BiP co-factor ERdj4 is up-regulated …

ERdj4 was shown to bind at significantly higher levels to the two mutant proteins than to WT SP-C, and siRNA-mediated decrease in ERdj4 expression led to a prolonged half-life for the …

在这篇综述中，我们的目的是阐明共同伴侣 ERDJ4（也称为 MDG1、MDJ7 或 DNAJB9）的功能。 敲除和敲入实验清楚地表明 ERDJ4 通过促进 SREBP1c 的降解和蛋白质复合物 mTORC2 …

the ERdj4 signal sequence is cleaved to yield a soluble protein. Importantly,wefoundthatbothendogenousandoverexpressed ERdj4 associate with the integral …

MDG1/ERdj4 is potently up-regulated in response to ER stress, indicating that this protein may play a role in either ER protein folding or in ER associated degradation (ERAD) to diminish the …

2021年8月5日 · A dual topology of the co-chaperone ERdj4, which resides in the endoplasmic reticulum (ER), was proposed recently, a thesis that we found to align all published data and …

2014年9月15日 · ER-localized DnaJ 4 (ERdj4) is a downstream effector of the IRE1α/XBP1 pathway [9]. ERdj4 belongs to the HSP40 family of cochaperones, which function to stimulate …

We show that two BiP cochaperones, endoplasmic reticulum-localized DnaJ homologues ERdj4 and ERdj5, play an essential role in ERAD of this nonglycosylated substrate.

2021年12月24日 · In this review, our aim is to elucidate the function of the co-chaperone ERDJ4, also known as MDG1, MDJ7, or DNAJB9. Knockout and knockin experiments clearly point to …