p44/42 MAPK (Erk1/2) Antibody detects endogenous levels of total p44/42 MAP kinase (Erk1/Erk2) protein. In some cell types, this antibody recognizes p44 MAPK more readily than p42 MAPK. The antibody does not recognize either JNK/SAPK or p38 MAP kinase. Human, Mouse, Rat, Hamster, Monkey, Mink, Zebrafish, Bovine, Pig, S. cerevisiae.

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) Antibody detects endogenous levels of p44 and p42 MAP Kinase (Erk1 and Erk2) when phosphorylated either individually or dually at Thr202 and Tyr204 of Erk1 (Thr185 and Tyr187 of Erk2).

Erk3 Antibody detects endogenous levels of total Erk3 protein. The antibody does not cross-react with other other Erk family members. Human, Mouse, Rat, Monkey. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu410 of human Erk3.

The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.

Theoretical MW 43 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Anti-MAPK Kinase (ERK-1, ERK-2) specifically reacts with both phosphorylated and unphosphorylated forms of ERK-1 and ERK-2 (44 and 42 kDa, respectively). Immunogen synthetic peptide corresponding to amino acids 317-339 derived from subdomain XI of human MAP kinase (ERK1).

Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.

2022年3月10日 · p-ERK Antibody (E-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects ERK phosphorylated at Tyr 204 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). p-ERK monoclonal ...

2024年10月12日 · ERK1/2是RAF-MEK-ERK信号通路的关键 组成部分，在Thr202、Tyr204位点被磷酸化从而激活，进而激活多种与细胞增殖、分化、迁移和血管生成相关的底物（超过160种）。 因此ERK1/2的 (Thr202, Tyr204)/ (Thr185, Tyr187)磷酸化是ERK激活的关键步骤，也是相关研究中不可或缺的检测指标。 ERK1/2宛如“风暴中的风眼”，RAS、RAF、MEK的突变激活均可导致ERK的过度激活，并持续激活ERK下游底物，导致肿瘤发生发展。 ERK有两种亚型：ERK1 …

ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.