ERK signalling: a master regulator of cell behaviour, life and fate
2020年6月23日 · We begin with a brief overview of the structure, regulation, substrate recognition and subcellular localization of ERK1 and ERK2. We then systematically discuss how ERK …
Live Visualization of ERK Activity in the Mouse Blastocyst Reveals ...
2020年11月9日 · FGF/ERK signaling is crucial for the patterning and proliferation of cell lineages that comprise the mouse blastocyst. Using an ERK-kinase translocation biosensor, Simon et …
Dynamic lineage priming is driven via direct enhancer regulation by ERK …
2019年11月6日 · Fibroblast growth factor-extracellular signal-regulated kinase (FGF -ERK) signalling drives differentiation of mouse embryonic stem cells (ES cells) and pre-implantation...
Generation of pulsatile ERK activity in mouse embryonic stem
2023年6月10日 · In this study, we established mouse ESC lines expressing the FRET biosensor EKAREV-NLS, and measured ERK signaling activity in individual ESCs in maintenance and …
Optogenetic manipulation identifies the roles of ERK and AKT …
Arekatla et al. use optogenetics to control ERK and AKT dynamics in mouse embryonic stem cells. Cumulative ERK activity over time—not duration, amplitude, or types of …
ERK phosphorylates ESRRB to regulate the self-renewal and ...
MEK (mitogen-activated protein kinase) inhibitor is widely used for culturing pluripotent stem cells, while prolonged MEK inhibition compromises the developmental potential of mouse embryonic …
NOTCH, ERK, and SHH signaling respectively control the fate
The E18.5 scATAC-Seq and P1 mouse cortical scRNA-seq data were from our previous study , GSE161132. ... L. B. Corson, Y. Yamanaka, K. M. Lai, J. Rossant, Spatial and temporal …
Intercellular propagation of extracellular signal-regulated kinase ...
2015年2月10日 · Extracellular signal-regulated kinase (ERK) is a key effector of many growth signalling pathways. In this study, we visualise epidermal ERK activity in living mice using an …
PNAS Plus: Erk signaling is indispensable for genomic stability and ...
2015年11月3日 · Here we demonstrate that Erk signaling is critical for mouse ESC self-renewal and genomic stability. Erk-depleted ESCs cannot be maintained. Lack of Erk leads to rapid …
FGF/ERK signaling is crucial for the patterning and proliferation of cell lineages that comprise the mouse blastocyst. Using an ERK-kinase translocation biosensor, Simon et al. show that the …
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