激活的ERK可以磷酸化c-Fos、c-Jun等转录因子，从而在细胞增殖和分化调节中起直接作用。 许多人类的肿瘤组织中都可发现MAPK-ERK信号通路处于异常高表达及高活性状态，促进肿瘤细胞增殖、分化、迁移和血管生成。

2020年6月23日 · We begin with a brief overview of the structure, regulation, substrate recognition and subcellular localization of ERK1 and ERK2. We then systematically discuss how ERK signalling regulates six...

Erk1/2 inhibition with either U0126 treatment or specific siRNA silencing resulted in decreases in p-ser STAT3 and cyclin D1 levels and increases in p-tyr STAT3 in OSCC cells. Moreover, Erk1/2 inhibition resulted in a dose-dependent reduction in OSCC cell growth and viability. Erk1/2 induction had the opposite effects.

MAPK/Erk 信号级联放大通过生长和分化中涉及的各种不同受体进行激活，包括受体酪氨酸激酶 (RTKs)、整合素以及离子通道。 由不同的刺激物激活的级联反应的特定组分差异较大，但通路的结构通常包含一组对接蛋白（Shc、GRB2、Crk 等），它们将受体连接到一个鸟苷酸交换因子上（SOS、C3G 等），信号则转导至小分子 GTP 结合蛋白 (Ras，Rap1)，后者再激活级联中的核心单位，包括一个 MAPKKK (Raf)、一个 MAPKK (MEK1/2) 和 MAPK (Erk)。 激活的 Erk 二聚 …

These results demonstrate that IFN-γ could up-regulate the expression of PD-L1, promote cell migration and transmission, and facilitate epithelial-mesenchymal transformation of breast cancer cells and this process may be related with ERK and Jak2-STAT signaling pathways.

2020年9月25日 · In this review, we briefly summarize the role of STAT2 in immune responses and carcinogenesis with respect to the molecular mechanisms of STAT2 stability regulation via the proteasomal...

Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) are members of the mitogen-activated protein kinase super family that can mediate cell proliferation and apoptosis. The Ras–Raf–MEK–ERK signaling cascade controlling cell proliferation has been well studied but the mechanisms involved in ERK1/2-mediated cell death are largely unknown.

2024年5月16日 · Janus激酶（JAK）信号转导和转录激活因子（JAK-STAT）途径是一种进化上保守的信号通路，由细胞因子刺激激活，使细胞外信号通过细胞膜传递到细胞核，引起DNA转录的改变，在几个关键的生理过程中发

2004年1月22日 · The JAK/STAT, Raf/MEK/ERK and PI3K/Akt signaling pathways elicited by IL-3 promote survival, growth and differentiation of pluripotent hematopoietic cells. A depiction of three pathways is ...

2022年11月14日 · 活化的磷酸化STAT（pSTAT）通过分子间SH2-磷酸酪氨酸相互作用形成同源或异源二聚化，易位到细胞核，结合DNA调控元件，改变染色质可及性，诱导基因转录（图3）。 图3 JAK-STAT信号转导. 05 细胞因子信号通路的负调控. 生理性负调控.