ERK differentially regulates Th17- and Treg-cell development and ...
In this report, we investigated the role of ERK, mitogen-activated protein kinase (MAPK), in Th17 and Treg cell development. We demonstrate that blockade of ERK activation inhibited Th17 …
Immunity | 万谊松组揭示Th17细胞两面性分化新机制 - 知乎
研究发现以表达细胞因子 IL-17 (Interlukin-17)和转录因子 RORγT 为典型特征的 Th17细胞 促进组织炎症发生，并在宿主抵抗病原体及自身免疫疾病的发病中起到重要作用。 但后续的研究发 …
ERK differentially regulates Th17‐ and Treg‐cell development and ...
2013年4月26日 · In this report, we investigated the role of ERK, mitogen-activated protein kinase (MAPK), in Th17 and Treg cell development. We demonstrate that blockade of ERK activation …
Berberine Differentially Modulates the Activities of ERK, p38 …
2009年10月9日 · We found that berberine inhibited Th17 differentiation by activating ERK1/2 and inhibited Th1 differentiation by inhibiting p38 MAPK and JNK activation. Berberine down …
ERK phosphorylation and miR-181a expression modulate
2015年3月16日 · In human memory T H 17 cells, miR-181a regulates responses to cognate antigens through modulation of ERK phosphorylation. By enhancing the signalling cascade …
ERK mitogen-activated protein kinase regulates Th17 cell …
2013年5月1日 · ERK inhibitor-treated Th17 cells function differently from proinflamamtory Th17 cells, in that ERK inhibitor-treated Th17 cells possessed suppressive function in vitro as they …
Pharmacologic Inhibition of MEK–ERK Signaling Enhances Th17 ...
2010年1月8日 · In this study, we report that pharmacologic inhibition of MEK–ERK signaling enhances the in vitro differentiation of Th17 cells and increases their gene expression of il …
ERK differentially regulates Th17‐ and Treg‐cell development and ...
2013年7月1日 · In this report, we investigated the role of ERK, mitogen‐activated protein kinase (MAPK), in Th17 and Treg cell development. We demonstrate that blockade of ERK activation …
Pharmacologic inhibition of MEK-ERK signaling enhances Th17 ...
2010年2月15日 · In this study, we report that pharmacologic inhibition of MEK-ERK signaling enhances the in vitro differentiation of Th17 cells and increases their gene expression of il …
KLHL25-ACLY module functions as a switch in the fate ... - Nature
2025年3月21日 · Naive CD4 + T cells transfected with Klhl25 targeting siRNAs were cultured under iTreg or Th17 polarization conditions in the presence (or absence) of ERK inhibitor and …