2024年12月25日 · ERP29 (Endoplasmic Reticulum Protein 29) is a Protein Coding gene. Diseases associated with ERP29 include Pharynx Squamous Cell Carcinoma and Congenital Hypothyroidism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein disulfide isomerase activity.

2009年9月21日 · Our study shows that ectopic expression of ERp29 in MDA-MB-231 cells results in G 0 /G 1 arrest, causes mesenchymal–epithelial transition (MET) and suppresses tumor growth in nude mice. We show a...

ERp29 is a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide-isomerase family. [6] However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. [6]

2025年2月9日 · ERp29 plays a critical role in protein folding, trafficking, and secretion, cell survival and apoptosis, and ER homeostasis. Though ubiquitously expressed, ERp29 is upregulated in response to ER stress and is found at higher levels in certain cell types such as secretory epithelial cells and neurons.

该基因编码一种定位于内质网 (ER) 腔的蛋白质。 它是蛋白质二硫化物异构酶 (PDI) 蛋白家族的成员，但缺乏活性硫氧还蛋白基序，表明该蛋白质不具有二硫化物异构酶的功能。 典型蛋白二聚化，被认为在 ER 内分泌蛋白的加工过程中发挥作用。 可变剪接导致编码不同异构体的多个转录变体。 [RefSeq 提供，2016 年 12 月] This gene encodes a protein which localizes to the lumen of the endoplasmic reticulum (ER).

2020年9月8日 · The luminal endoplasmic reticulum (ER) protein of 29 kDa (ERp29) is a ubiquitously expressed cellular agent with multiple critical roles. ERp29 regulates the biosynthesis and trafficking of several transmembrane and secretory proteins, including the cystic fibrosis transmembrane conductance regulato …

ERp29 controls invasion and metastasis of gastric carcinoma by inhibition of epithelial-mesenchymal transition via PI3K/Aktsignaling pathway. Ye J, et al. BMC Cancer, 2017 Sep 6. PMID 28874138, Free PMC Article.

2015年9月30日 · Our previous studies have demonstrated a significant role of ERp29 in breast cancer cell survival against doxorubicin-induced genotoxic stress. We here reported that ERp29 expression in the...

2015年1月30日 · The endoplasmic reticulum (ER) protein 29 (ERp29) is a molecular chaperone that plays a critical role in protein secretion from the ER in eukaryotic cells. Recent studies have also shown that ERp29 plays a role in cancer. It has been demonstrated that ERp29 is inversely associated with primary tumor …

The molecular chaperone endoplasmic reticulum protein 29 (ERp29) plays a critical role in protein folding, trafficking, and secretion. Though ubiquitously expressed, ERp29 is upregulated in response to ER stress and is found at higher levels in certain cell types such as secretory epithelial cells a …