2013年5月20日 · Here, we review the effects of subunit composition on NMDAR properties, synaptic plasticity and cellular mechanisms implicated in neuropsychiatric disorders. …

We show that glycine-independent desensitization is controlled by N-terminal domains of the NR2 subunit that flank the putative agonist-binding domain: a four amino acid (aa) segment …

In mature cultured neurons, NR2A-NMDARs promote, whereas NR2B-NMDARs inhibit, the surface expres-sion of GluR1, primarily by regulating its surface in-sertion. In mature neurons, …

2008年8月1日 · Fukaya et al. 63 showed that NR1 was vital for the release of NR2 subunits from the ER in hippocampal pyramidal cells in vivo: in the absence of NR1, the NR2 subunits are …

2001年11月1日 · Here we show that the NR2 receptor is recognized by both murine and human anti-DNA antibodies. Moreover, anti-DNA antibodies with this cross-reactivity mediate …

2003年1月1日 · NMDA receptors are composed of seven known subunits (NR1, NR2A–D, NR3A–B). The present review focuses on the NR2B subunit of the receptor. Over the last …

2007年9月30日 · We evaluated the potency and efficacy of a wide range of glutamate-like compounds at NR1/NR2A, NR1/NR2B, NR1/NR2C, and NR1/NR2D receptors. Twenty-five of …

2025年2月25日 · Huang et al. present the cryo-EM structures of human GluN1-N2B receptors in the Mg2+ bound and Mg2+ free states and identify three Mg2+-binding sites with distinct …

The incorporation of different NR2 subunits has a major impact on the functional properties of the NMDA receptor, critically influencing agonist and antagonist affinity, receptor deactivation …

2007年4月22日 · Four different NR2 subunits (NR2A-D) have been identified with distinct expression and functional profiles (Erreger et al., 2004). This heterogeneity among NMDA …