Phenotypic Switching of Vascular Smooth Muscle Cells in …
2023年10月10日 · Stem/endothelial/monocyte‐like (SEM‐like) cells were first reported by Pan et al, 14 who studied a VSMC‐lineage tracing murine model and human carotid artery …
Targeting smooth muscle cell phenotypic switching in vascular disease
2021年5月15日 · We summarize findings on new epigenetic (DNA methylation/TET methylcytosine dioxygenase 2, histone deacetylation, bromodomain proteins), transcriptional …
Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis
2021年5月24日 · The concept of vascular smooth muscle cells (VSMCs) existing in a “transitional stage between smooth muscle and foam cells” of a human atheroma was first postulated in …
Smooth muscle cell-driven vascular diseases and molecular
In this article we introduce the physiological functions of vascular smooth muscle/VSMCs, outline VSMC-driven cardiovascular diseases and the concept of VSMC phenotype switching, and …
来自活化血管平滑肌细胞的细胞外陷阱驱动动脉粥样硬化的进 …
从 cd68 + vsmc 产生的明显 et 在体外被 cl-脒和 dnase i 抑制。通过利用 vsmc 谱系追踪技术和单细胞 rna 测序 (scrna-seq)，我们证明来自 cd68 + vsmc 的 et 通过 sting-socs1 或 tlr4 信号通 …
Vascular smooth muscle cells in atherosclerosis - PMC
We review the effect of embryological origin on VSMC behavior in atherosclerosis, the role, regulation and consequences of phenotypic switching, the evidence for different origins of …
Vascular smooth muscle cell phenotypic switching in atherosclerosis
2024年9月30日 · Vascular smooth muscle cells (VSMCs) are the predominant cell type in normal arteries, and under atherosclerotic stimuli, VSMCs respond to altered blood flow and …
How vascular smooth muscle cell phenotype switching contributes …
Vascular injury stimulates VSMCs to switch into a dedifferentiated type, also known as synthetic VSMCs, with a high migration and proliferation capacity for repairing vascular injury.
Smooth muscle cell-driven vascular diseases and ... - ScienceDirect
2018年12月1日 · In this article we introduce the physiological functions of vascular smooth muscle/VSMCs, outline VSMC-driven cardiovascular diseases and the concept of VSMC …
Vascular smooth muscle cells in atherosclerosis - Nature
2019年6月26日 · VSMC functions are key determinants of the properties of vessels throughout the arterial tree; VSMC-derived elastin is crucial for elastic recoil in large elastic arteries (such …