2023年10月10日 · Stem/endothelial/monocyte‐like (SEM‐like) cells were first reported by Pan et al, 14 who studied a VSMC‐lineage tracing murine model and human carotid artery atherosclerotic plaques, and observed the transition of VSMCs to a multipotent intermediate cell …

2021年5月15日 · We summarize findings on new epigenetic (DNA methylation/TET methylcytosine dioxygenase 2, histone deacetylation, bromodomain proteins), transcriptional (Hippo/Yes-associated protein, peroxisome proliferator-activity receptor-gamma, Notch), and β3-integrin-mediated mechanisms that influence VSMC phenotypic modulation.

2021年5月24日 · The concept of vascular smooth muscle cells (VSMCs) existing in a “transitional stage between smooth muscle and foam cells” of a human atheroma was first postulated in 1961 with the aid of an electron microscope. 1 This proposition gained further support with the development of molecular probes to identify cell-restricted genes or their ...

In this article we introduce the physiological functions of vascular smooth muscle/VSMCs, outline VSMC-driven cardiovascular diseases and the concept of VSMC phenotype switching, and review molecular mechanisms that play crucial roles in the regulation of VSMC phenotypic plasticity.

从 cd68 + vsmc 产生的明显 et 在体外被 cl-脒和 dnase i 抑制。通过利用 vsmc 谱系追踪技术和单细胞 rna 测序 (scrna-seq)，我们证明来自 cd68 + vsmc 的 et 通过 sting-socs1 或 tlr4 信号通路调节 vsmc 的转分化方向来影响动脉粥样硬化的进展。

We review the effect of embryological origin on VSMC behavior in atherosclerosis, the role, regulation and consequences of phenotypic switching, the evidence for different origins of VSMCs, and the role of individual processes that VSMCs undergo in atherosclerosis in regard to plaque formation and the structure of advanced lesions.

2024年9月30日 · Vascular smooth muscle cells (VSMCs) are the predominant cell type in normal arteries, and under atherosclerotic stimuli, VSMCs respond to altered blood flow and microenvironment changes by downregulating contractile markers and switching their phenotype.

Vascular injury stimulates VSMCs to switch into a dedifferentiated type, also known as synthetic VSMCs, with a high migration and proliferation capacity for repairing vascular injury.

2018年12月1日 · In this article we introduce the physiological functions of vascular smooth muscle/VSMCs, outline VSMC-driven cardiovascular diseases and the concept of VSMC phenotype switching, and review molecular mechanisms that play crucial roles in the regulation of VSMC phenotypic plasticity.

2019年6月26日 · VSMC functions are key determinants of the properties of vessels throughout the arterial tree; VSMC-derived elastin is crucial for elastic recoil in large elastic arteries (such as the aorta),...