2024年7月23日 · Chimeric viruses were used to demonstrate that viral structural protein VP1 determines growth in the spinal cord, motor neuron loss, and paralysis following intramuscular …

2018年11月5日 · The capsid of EV-D68 contains 60 copies of each of four proteins VP1 to VP4, arranged with pseudo T = 3 symmetry 9. The capsid accommodates deep surface …

VP1 is the primary determinant of enterovirus serotype, plays a major role in antigenicity , and is the site of receptor binding (15, 17). Therefore, variation in VP1 sequences is likely a …

2023年5月17日 · Analysis of the amino acid sequences in the VP1 variable loops of 2021 and 2022 B clade viruses using the Nextstrain resource indicates that most isolates maintain the …

VP1 is the primary determinant of neuropathogenesis in a mouse model of enterovirus D68 acute flaccid myelitis. J Smith Leser. ... Having ruled out EVD68 non-structural proteins and 3’UTR …

Part of the VP1 GH loop (residues 212–215) that forms the entrance to the VP1 pocket had become less ordered. The Cα atom of residue 211 had moved 1.2 Å towards the inside of the …

2024年10月19日 · P25, derived from the HI loop and β-I sheet of VP1, operates through a conserved hydrophilic motif -R---K-K--K- and the hydrophobic F near the N-terminus. It could …

摘要 目的:通过对人肠道病毒D68型(EV-D68)衣壳蛋白VP1理化性质、结构功能和B细胞表位分析,获取候选疫苗肽段用于后期疫苗研制。 方法:应用Bioedit软件、Netphos和ExPASy等在线工具分 …

2018年11月1日 · We observed that A6-1 bound to the DE loop of EV-D68 VP1 and interfered with the interaction between the EV-D68 virus and α2,6-linked sialic acids of the host cell. The …

Non-transfected (–) and transfected (+) 293T whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Enterovirus D68 VP1 antibody (GTX132313) …