Extravillous trophoblast (EVT) cells migrate from anchoring villi, and invade into the decidua basalis. Their main function is remodelling the uterine spiral arteries, to achieve an increase in the spiral artery diameter of from four to six times.

2023年8月10日 · EVT cells are terminally differentiated trophoblast cells that invade into and restructure the uterine compartment, including transforming tightly coiled spiral...

2018年7月24日 · New subtypes of cells of the known cytotrophoblast cells (CTBs), extravillous trophoblast cells (EVTs), Hofbauer cells, and mesenchymal stromal cells were identified and...

2023年3月29日 · Extravillous trophoblast cells (EVTs) derived from placental villi infiltrate the decidua, transforming the maternal arteries into high-conductance vessels 1. Defects in...

一旦去除所有生长因子和WNT激活剂，但保持TGFβ抑制，并添加NRG1（Neuregulin 1），我们就能够有效地从类器官中产生EVT。添加NRG1是基于报告显示蜕膜衍生的NRG1促进胎盘外植体培养中EVT的形成和存活，随后用于在体外将TSC分化为EVT 7,38。

2023年3月1日 · Result6 人类滋养细胞祖细胞有助于EVT分化 VCT-3作为一个活跃的增殖亚群（图4E），具有VCT到EVT分化的基因表达特征（图4D和5A）。 因此作者通过免疫荧光和染色（图5B-D）发现，VCT-3中的细胞充当有丝分裂活性的滋养层祖细胞，具有形成EVT生长的潜力。

2024年9月26日 · Notum, palmitoleoyl-protein carboxylesterase (NOTUM), a negative regulator of canonical WNT signaling, was prominently expressed in first-trimester EVT cells developing in situ and up-regulated in EVT cells derived from human TS cells. Furthermore, NOTUM was required for optimal human TS cell differentiation to EVT cells. Activation of NOTUM in ...

2023年10月18日 · EVT, derived from villous cytotrophoblast (CTB) through cytotrophoblast cell column (CCC), has unique human leucocyte antigen (HLA) expression profile (positive for HLA-C, HLA-G, HLA-E and HLA-F and negative for HLA-A and HLA-B), and can finally fuse to produce multinucleated placental bed giant cells (GCs) [5].

2024年12月1日 · Here, we studied the effect of modulating autophagy and ox-LDL in a model of EVT cells (HTR-8/SVneo) and we demonstrated that autophagy is essential for the acquisition of the endothelial-like phenotype of extravillous trophoblast …

2014年1月28日 · Term basal plate may be a viable source of functional EVT cells that is an alternative to villous explant-derived EVT cells and cell lines. Isolated term EVT cells may be particularly useful in investigation of the role of trophoblast cells in pathological gestations, in which the precise regulation …