2024年8月23日 · Exemestane (brand name Aromasin) is an aromatase inhibitor used to lower estrogen levels in women past menopause with early or advanced hormone-sensitive breast cancer. Early breast cancer is cancer that has not spread outside the breast. Advanced breast cancer is cancer that has spread to other parts of the body.

依西美坦 （INN: exemestane，商品名Aromasin，台灣譯名諾曼癌素）是治療 乳癌 的抗雌激素藥物，屬於芳香化酶抑制劑。 某些乳癌細胞具有雌激素 受体 （ER），受 雌激素 刺激而生長，被稱為ER陽性（或稱雌激素反應性、激素反應性或激素受體陽性乳癌）。 芳香化酶 是合成雌激素的 酶，使用其抑制劑可阻止雌激素的合成，以減緩腫瘤的生长。 依西美坦的適應症是治療停經後雌激素受體陽性早期乳癌病人，術後曾接受過tamoxifen治療二至三年，可轉用本藥完成共計五年的 …

Exemestane is used to treat early and advanced breast cancer in women who have already stopped menstruating (postmenopausal). It is usually used in women who have already received a cancer medication called tamoxifen. Many breast cancer tumors grow in response to estrogen. Exemestane interferes with the production of estrogen in the body.

依西美坦，化学名称为6-亚甲基雄甾-1,4-二烯-3,17-二酮，是一种有机化合物，化学式为C20H24O2，为白色至淡黄色结晶性粉末，溶于甲醇，不溶于水，是一种抗肿瘤药，临床上适用于以他莫昔芬治疗后病情进展的绝经后晚期乳腺癌患者。 化学式：C20H24O2. 分子量：296.403. CAS号：107868-30-4. 密度：1.13 g/cm 3. 熔点：155.1°C. 沸点：453.7ºC. 闪点：169ºC. 折射率：1.572. 外观：白色至淡黄色结晶性粉末. 溶解性：溶于甲醇，不溶于水 [1] 摩尔折射 …

Exemestane Study）（见【临床试验】）和027研究（特别设计的随机、安慰剂对照、双盲、平行 研究以评价依西美坦治疗2年以上对骨代谢、激素、脂质和凝血因子影响）。

2024年8月19日 · Exemestane belongs to a class of medicines called aromatase inhibitors. It works by blocking an enzyme called aromatase that helps produce estrogen in the body. By lowering the amount of...

Exemestane is an irreversible, steroidal aromatase inactivator of type I, structurally related to the natural substrate 4-androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as " suicide ...

Exemestane is used to treat early breast cancer in women who have experienced menopause ('change of life'; end of monthly menstrual periods) and who have already been treated with a medication called tamoxifen (Nolvadex) for 2 to 3 years.

Exemestane reduces the amount of oestrogen in the body. It blocks an enzyme (a type of protein) that helps produce oestrogen in the fatty tissues of the body. You have exemestane as tablets you can take at home. You may have exemestane with other cancer drugs. During your treatment, you will meet someone from your cancer team, such as a:

Exemestane tablets, USP are used in women who are past menopause for the treatment of: Early breast cancer (cancer ...