3. 外显子 （expressed region），是真核生物基因的一部分，它在剪接后仍会被保存下来，并可在蛋白质生物合成过程中被表达为蛋白质。 外显子是最后出现在成熟RNA中的基因序列，又称表达序列。

Hot-spot exon mutations of CTNNB1 can drive tumorigenesis. Exon 3 of CTNNB1 is a key exon encoding serine-threonine phosphorylation sites for GSK-3β that activates degradation of β-catenin . The CTNNB1 mutations are frequently missense mutations .

KRAS Exon 3 Mutation is an inclusion criterion in 4 clinical trials for non-small cell lung carcinoma, of which 3 are open and 1 is closed. Of the trials that contain KRAS Exon 3 Mutation and non-small cell lung carcinoma as inclusion criteria, 1 is phase 1 (0 …

2017年11月24日 · Mutations of the CTNNB1 gene that encodes β-catenin occur in a wide spectrum of cancers. These mutations alter the spatial characteristics of the β-catenin protein, leading to drastic reprogramming of the nuclear transcriptional network.

An exon – EXpressed regiON - is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing. The term exon refers to both the DNA sequence within a gene and to the corresponding sequence in RNA transcripts.

Exon 3 encodes a portion of the extracellular domain of the receptor and its absence or presence results in differential GH-binding abilities [44,45]. Since then, a wide range of studies have examined how this GHR polymorphism affects people with various conditions.

2023年5月3日 · PD-L1 exon 3 is a potential alternative exon and encodes an Ig variable (IgV) domain. Here, we found that a lack of exon 3 leads to the significant loss of cellular membrane locations and the dramatically reduced protein expression of PD-L1, indicating that PD-L1 exon 3 is essential for its protein expression and translocation to the cell membrane.

2023年3月15日 · 外显子(exon)是DNA上的编码区域，它可以被转录形成前体RNA(pre-mRNA)，并在RNA剪切后的成熟RNA中留存。 因此，这个术语也能够被用于其对应的成熟RNA中的序列。

2018年5月24日 · CTNNB1 (encodes β-catenin) mutations identify a subset of low-grade, early-stage endometrial cancer patients at high risk of recurrence. Mutation of CTNNB1 exon 3 is classically associated with...

2021年7月3日 · We aimed to assess the prognostic value of KRAS exons 3 and 4 mutations to determine the necessity for their testing. Methods: KRAS mutations in exon 2/3/4 were evaluated in 1816 stage I-IV patients with colorectal adenocarcinoma. Results: The mutation rates of KRAS and KRAS exons 2, 3, and 4 were 49.0%, 43.0%, 1.9%, and 4.1%, respectively.