Extracellular matrix and its therapeutic potential for cancer …
2021年4月23日 · The extracellular matrix (ECM) is one of the major components of tumors that plays multiple crucial roles, including mechanical support, modulation of the microenvironment, and a source of ...
The extracellular matrix as hallmark of cancer and metastasis: …
2024年1月4日 · The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a critical role in cancer. Although research often concentrates on the tumor's cellular aspect, attention is growing for the importance of the cancer-associated ECM. Biochemical and physical ECM signals affect …
The extracellular matrix as hallmark of cancer and metastasis
2024年1月3日 · The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a critical role in cancer. Although research often concentrates on the tumor’s cellular aspect, attention is growing for the importance of the cancer-associated ECM.
The Functional Role of Extracellular Matrix Proteins in Cancer
We describe the mechanisms of how the protein composition and structure of the extracellular matrix changes during cancer progression and how abnormal matrix deregulates the behavior of stromal cells and influences cancer progression.
Concepts of extracellular matrix remodelling in tumour ... - Nature
2020年10月9日 · In this review, we discuss remodelling mechanisms of extracellular matrices and the implications of these mechanisms during cancer development, and describe recent concepts of ECM remodelling...
Extracellular matrix-derived mechanical force governs breast cancer …
2023年6月28日 · In this study, we aimed to explore the influence of ECM-derived biomechanical force on breast cancer cell status. Experiments were conducted using 3D collagen, fibrinogen, and Matrigel matrices...
Extracellular matrix and its therapeutic potential for cancer
2021年4月23日 · The extracellular matrix (ECM) is one of the major components of tumors that plays multiple crucial roles, including mechanical support, modulation of the microenvironment, and a source of signaling molecules. The quantity and cross-linking status of ECM components are major factors determining tiss …
Extracellular matrix-based cancer targeting - Cell Press
2021年8月10日 · Modified extracellular matrix in the tumor microenvironment dictates cancer cell properties, metastatic potential, and formation of premetastatic niches. Proteoglycans and hyaluronan in provisional matrix modulate the bioavailability of matrix-bound effectors, cancer cell signaling, angiogenesis, and tumor spread.
Extracellular Matrix in the Tumor Microenvironment and Its …
Understanding the particularities of the ECM in solid tumor is necessary to develop approaches to interfere with its negative effect. In this review, we will also highlight the current understanding of the physical, cellular, and molecular mechanisms by which the pathological tumor ECM affects the efficiency of radio-, chemo-, and immunotherapy.
The extracellular matrix modulates the hallmarks of cancer
2014年11月10日 · This review discusses how the biochemical and biophysical properties of the extracellular matrix evolve during tumor progression and how they critically impact the behavior of tumor and stromal cel...