Notch Ligands Expressed by Follicular Dendritic Cells Protect …
2009年7月1日 · In this study, we investigated the functional roles of Notch signaling in human B cell differentiation within the germinal center (GC). Notch ligands, Delta-like 1 (Dll1) and …
Notch signaling represents an important checkpoint between
2018年2月21日 · Given the importance of Notch signaling in the establishment of other CD4+ T-helper cell subsets, we investigated whether canonical Notch activation could differentially …
Follicular dendritic cells: origin, phenotype, and function in health ...
2014年3月1日 · Human tonsillar FDCs express ligands for Notch, and in vitro experiments using FDC cell lines and GC B cells, showed reduced GC B cell survival upon blocking Notch …
B细胞免疫反应中的Notch信号通路 - 知乎
2024年2月11日 · Notch信号通路是由细胞表面的 Notch配体 （属于Jagged和 Delta-like 家族的蛋白质成员）与相邻细胞上的Notch受体相互作用而被激活。 Notch受体家族及其配体是高度保 …
Notch Signaling in B Cell Immune Responses - PMC
Notch signaling is initiated by the interaction of cell-surface-bound Notch ligands (members of the Jagged and Delta-like families of proteins) to Notch receptors on adjacent cells. The Notch …
Notch2-mediated plasticity between marginal zone and
2021年2月17日 · Follicular B (FoB) and marginal zone B (MZB) cells are functionally and spatially distinct mature B cell populations in the spleen, originating from a Notch2-dependent fate …
血管内皮notch信号的缺失促进三级淋巴结构自发形成 - 知乎
作者分析了Notch基因在欧洲肾脏cDNA库（ERCB）队列库中与TLS生成相关的各种肾脏疾病中的表达，比较健康活体肾脏捐献者（LD）的肾活检RNA测序数据集与各种形式的炎症性肾病， …
滤泡树突状细胞_百度百科
滤泡树突状细胞 (FDC),与一般的 树突状细胞 (DC)功能不同,它不表达MHC-II类分子,其细胞表面有丰富的抗体受体,可与抗原-抗体复合物结合,只有表达与抗原高亲和力抗体的B细胞才能与FDC …
经典信号通路总结——Notch信号通路 - 知乎
Notch 通路主要由四部分组成： Notch受体、Notch配体、CSLDNA结合蛋白、下游靶基因。 上述四部分中任何一个因素改变都会对 Notch信号通路 传递产生影响。
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