FDG-PET has been proven to be a promising modality for detecting functional brain changes in AD, identifying changes in early AD, and helping to differentiate AD from other causes of dementia. Many studies have been published evaluating the value of FDG-PET in AD for the last 3 …

2014年12月24日 · FDG PET shows a pattern of glucose hypometabolism in the posterior cingulate and parahippocampal gyri in amnestic MCI, gradually spreading to involve the bilateral temporal lobes (middle and inferior temporal gyri) and the parietal lobes in AD, extending to the prefrontal cortex with advancing disease.

2017年7月13日 · fdg pet 用于测量神经元和胶质细胞的葡萄糖摄取情况，被认为是突触功能变化最敏感的指标。 AD 患者可出现典型的颞顶区、后扣带回皮质和楔前叶葡萄糖代谢降低，具有 90% 敏感性以识别出 AD 与其他类型痴呆。

2023年9月8日 · FDG-PET 在视觉和定量感知这类发现中起重要作用，从而可以提高 AD 临床诊断准确性，并有可能鉴别AD和非阿尔茨海默病痴呆。 此外，FDG-PET可作为早期诊断AD、轻度认知障碍 (MCI)或临床前阶段的生物标志物。 作为治疗前或非药物治疗，以及疗效评估的生物标志物。 通常，在诊断AD时，计算机断层扫描 (CT)和MRI是排除正常压力脑积水和慢性硬膜下血肿等可治疗性痴呆和评估脑血管疾病的必要手段。 而单光子发射 CT (SPECT)和 PET 则可分别评价脑 …

2019年6月29日 · Reduced 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET) brain metabolism was recognized as a biomarker of neurodegeneration in the recently proposed ATN framework for Alzheimer’s disease (AD) biological definition. However, accumulating evidence suggested it is an independent biomarker, which is denoted as “F” in the very study.

2020年5月7日 · We aim to present and critically evaluate the use of FDG-PET in the differential diagnosis between dementing conditions including Alzheimer disease (AD), frontotemporal dementia (FTD) and its variants, vascular dementia (VaD) and pseudodepressive dementia.

FDG-PET is a valuable tool that will continue to aid in identifying AD in its prodromal and early dementia stages, distinguishing it from other causes of dementia, and tracking progression of the disease. As brain FDG-PET scans and well-trained readers of these scans are becoming more widely availab …

6 天之前 · Purpose This study aims to calculate the diagnostic performance of deep learning (DL)-assisted 18F-fluorodeoxyglucose ([18F]FDG) PET imaging in Alzheimer’s disease (AD). Methods The Ovid MEDLINE, Ovid Embase, Web of Science Core Collection, Cochrane, and IEEE Xplore databases were searched for related studies from inception to May 24, 2024. We included original studies that developed a DL ...

2024年12月4日 · 在fdg-pet研究中，典型的ad模式表现为明显的顶颞区低代谢；而在mri研究中，典型的ad模式则表现为皮层和海马体的广泛萎缩。 已有研究对AD患者的FDG-PET和MRI成像进行了比较。

2 天之前 · In AD, p-tau181 and p-tau217 predict cognitive decline at 1 year and correlate with Aβ PET and tau PET positivity 114,115. p-tau217 demonstrated Aβ-correlated changes over 4–6 years in both ...