Fibroblast growth factor 10 is a paracrine signaling molecule seen first in the limb bud and organogenesis development. FGF10 starts the developing of limbs and its involved in the branching of morphogenesis in multiple organs such as the lungs, skin, ear and salivary glands.

2024年12月25日 · FGF10 (Fibroblast Growth Factor 10) is a Protein Coding gene. Diseases associated with FGF10 include Aplasia Of Lacrimal And Salivary Glands and Lacrimoauriculodentodigital Syndrome 3. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Downstream signaling of activated FGFR2.

成纤维细胞生长因子 FGF（Fibroblast Growth Factors，FGFs）最初是以其成纤维细胞的有丝分裂能力命名的。 FGF及其受体在动物界高度保守。 在哺乳动物中， FGF家族 包括23种多肽，它们调节多种细胞的迁移、增殖、分化、存活、代谢活动和神经功能。 FGF家族成员. FGF家族至少有20个成员，命名为FGF-1到FGF-20，但 酸性FGF 和 碱性FGF 是FGF-1和FGF-2的常用名称，而 角质形成细胞生长因子 （KGF）是FGF-7的常用名称。 酸性FGF（aFGF）和碱 …

2016年4月1日 · FGF10, which is a mesenchymal signaling molecule in the epithelium, is essential for the development of multiple organs. FGF10 also plays roles in epithelial–mesenchymal transition, the repair of tissue injury, and embryonic stem cell differentiation. In humans, FGF10 mutations result in inherited diseases.

该基因编码的蛋白质是成纤维细胞生长因子 (FGF) 家族的成员。 FGF 家族成员具有广泛的促有丝分裂和细胞存活活性，并参与多种生物过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。 该蛋白对角化表皮细胞表现出促有丝分裂活性，但对成纤维细胞基本上没有活性，这与 FGF7 的生物学活性相似。 对小鼠同系物的研究表明，该基因是胚胎表皮形态发生所必需的，包括大脑发育、肺形态发生和肢芽形成的启动。 该基因也被认为是伤口愈合过程中的主要 …

The FGF10 gene provides instructions for making a protein called fibroblast growth factor 10 (FGF10). This protein is part of a family of proteins called fibroblast growth factors that are involved in important processes such as cell division, regulation of cell growth and maturation, formation of blood vessels, wound healing, and development ...

fgf10和fgfr2b分别在间质和上皮中优先表达。 FGF10是上皮中的间充质信号分子。 由于完全没有肺以及前肢和后肢，FGF10基因敲除小鼠出生后不久就死亡。

Fgf10 is an epithelial-mesenchymal signaling molecule. Fgf10 knockout mice show severe phenotypes with complete truncation of the fore- and hindlimbs and die shortly after birth due to impaired lung development, indicating that Fgf10 serves as an essential regulator of …

KGF-2/ FGF-10 Protein, Human (169a.a) 是一种肝素结合蛋白，与 FGF2 IIIb 和 FGFR1III-b 受体结合，能够促进上皮细胞的生长、增殖、分化，并且增强角膜伤口的愈合。 KGF-2/FGF-10蛋白协调胚胎发育、调节细胞增殖和分化，并且在分支形态发生中是不可或缺的。 这种多功能蛋白质可能有助于伤口愈合。 Animal-Free KGF-2/ FGF-10 Protein, Human (His) 是重组的 无动物源 KGF-2/ FGF-10 蛋白，由 E. coli 表达，带有 C-His, C-His 标签。

Fibroblast growth factor 10 (FGF10) is a major morphoregulatory factor that plays essential signaling roles during vertebrate multiorgan development and homeostasis. FGF10 is predominantly expressed in mesenchymal cells and signals though FGFR2b in adjacent epithelia to regulate branching morphogene …