The FGFR1 gene is located on human chromosome 8 at position p11.23 (i.e. 8p11.23), has 24 exons, and codes for a Precursor mRNA that is alternatively spliced at exons 8A or 8B thereby generating two mRNAs coding for two FGFR1 isoforms, FGFR1-IIIb (also termed FGFR1b) and FGFR1-IIIc (also termed FGFR1c), respectively. Although these two isoforms ...

2024年12月25日 · FGFR1 is a member of the Fibroblast Growth Factor family, comprising of 4 receptors and 18 Ligands. FGFR1 signalling downstream functions mainly via PI3K and MAPK pathways (Turner et. al.). Several ways of involvement of FGFR1 in cancer have been proposed: auto- and paracrine activation, amplification and overexpression (Marshall et. al, Weiss ...

成纤维细胞生长因子受体 （fgfr）包括fgfr1, fgfr2, fgfr3, fgfr4及fgfrl1(缺少胞内激酶结构域），由不同基因编码，但结构功能相似，为单次跨膜蛋白，有胞外区，跨膜区，胞内激酶区域组成。fgfr会出现多种形式的选择性剪切，如外显子1和3的缺失，c-端截断等。

The FGFR1 gene provides instructions for making a protein called fibroblast growth factor receptor 1 (FGFR1). This protein is one of four fibroblast growth factor receptors, which are a family of proteins that are involved in processes such as cell division, regulation of cell growth and maturation, formation of blood vessels, wound healing ...

FGFR1 amplification was identified in all types of lung carcinoma; results demonstrated upregulation of FGFR1 and cytokeratin 20 expressions in cancer bladder tissues; FGFR1 dimers forms a complex with its effector PLCgamma1.

2020年9月2日 · FGFs exert their pleiotropic effects by binding and activating high-affinity tyrosine kinase receptors that are coded by four genes

2024年6月20日 · 通过对fgfr1-4基因不同变异类型检测，可覆盖多种肿瘤，如扩增主要见于乳腺癌、胃癌及肺癌；获得性功能突变主要见于乳腺癌、子宫内膜癌、肉瘤及肺癌等；基因融合可见于膀胱癌、胆管癌、恶性胶质瘤及肺癌等，而配体基因的变异情况往往也是fgfr抑制剂药物 ...

处于招募状态有2项：以长春瑞滨、多西他赛或pembrolizumab为对照，治疗晚期尿路上皮癌的 erdafi tinib ；招 募FGFR1或FGFR3高表达的晚期或转移性尿路上皮癌（FRT-1）患者，以化疗（多西紫杉醇、紫杉醇或长春瑞滨）为对照，进行 rogaratinib （BAY1163877）疗效研究。

2025年2月8日 · PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1 NM_001354370.2 → NP_001341299.1 fibroblast growth factor receptor 1 isoform 18 precursor Status: REVIEWED

fgfr1是位于8号染色体的基因。 本词条缺少概述图，补充相关内容使词条更完整，还能快速升级，赶紧来 编辑 吧！