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LL-37 FK-13就是LL-37衍生的短α-螺旋抗菌肽中的一种，由13个 氨基酸组成，具有很高的细胞选择性和抗炎活性。 研究表明LL-37 FK-13可以通过渗透细胞膜和破坏膜的完整性来杀死微生物细胞。 LL-37的核心序列FK-13被肌动蛋白保护免受细菌蛋白水解。 FK-13表现出抗HIV-1、EC的活性₅₀ 3.4微米。 由于N-末端 苯丙氨酸 的去除导致失活，FKRIVQRIKDFLR对应于人类LL-37的最小抗HIV区域。 FK-13, core sequence of LL-37, is protected from bacterial proteolysis by actin. …

The adjuvant characteristics of an antimicrobial peptide-derived core peptide, FK-13, are investigated and used it to generate a fusion peptide named FK-33 with tumor antigen epitopes. l-phenylalanine-based poly (ester amide) (Phe-PEA), 8p4, is also identified as a competent delivery vehicle for the fusion peptide FK-33.

Using amino acid substitution, we designed and synthesized a series of FK13 analogs based on the sequence of the 13-meric short FK13 peptide (residues 17-29 of LL-37) that has been identified as the region responsible for the antimicrobial activity of LL-37.

LL-37 FK-13就是LL-37衍生的短α-螺旋抗菌肽中的一种，由13个氨基酸组成，具有很高的细胞选择性和抗炎活性。 研究表明LL-37 FK-13可以通过渗透细胞膜和破坏膜的完整性来杀死微生物细胞。 保存方法:-20℃下冷冻干燥、避光保存. 备注：仅用于研究，不用于人体. 订购方式： 杭州固拓生物科技有限公司. 电话：+86-571-88211921; +86-571-88211951. 手机： +86-13355716090; +86-13735575465 （同微信号） QQ: 2106744140 ； 3187976021； 477994683. 邮 …

A Nanovaccine Based on Adjuvant Peptide FK-13 and l-Phenylalanine Poly(ester amide) Enhances CD8+ T Cell-Mediated Antitumor Immunity. Adv Sci (Weinh). 2023 May 10:e2300418. doi:...

Futbol Klub 13 (Bulgarian: Футбол клуб 13), or simply FK 13 Sofia was a Bulgarian football club based in Sofia. In its history the club has won two Bulgarian Cups in 1938 [1] and 1940. [2] Football Club 13 existed independently between 1909 and 1944.

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These results indicate that short peptide FK-13, derived from AMP LL-37, could promote antigen presentation and enhance the functions of CD8 + T cells and DCs. Based on these findings, we hypothesize that FK-13 can act as an adjuvant in cancer vaccines and bridge innate immunity and adaptive immunity for a stronger antitumor immune response.

2017年5月1日 · Using amino acid substitution, we designed and synthesized a series of FK13 analogs based on the sequence of the 13-meric short FK13 peptide (residues 17–29 of LL-37) that has been identified as the region responsible for the antimicrobial activity of LL-37.