Here, we describe the identification of a new locus, FLS2, by a map-based strategy. The FLS2 gene is ubiquitously expressed and encodes a putative receptor kinase. FLS2 shares structural and functional homologies with known plant resistance genes and with components involved in the innate immune system of mammals and insects.

FLS2 and FLS1 are different genes with different responsibilities, but are related genetically. FLS2 has a specific focus in plant defense and is involved in promoting the MAP kinase cascade. Mutations in the FLS2 gene can cause bacterial infection by lack of response to flg22.

2024年3月11日 · The signal perception mechanism of FLS2 in Arabidopsis has been extensively investigated. FLS2 consists of an LRR domain, a single transmembrane domain (TM), and an intracellular kinase domain (KD). The extracellular region of FLS2 contains LRRs, which are primarily responsible for recognizing the flagellar peptide flg22 (Sun et al., 2013).

2019年11月1日 · Here the authors show that NIK1, an RLK that positively regulates antiviral immunity, negatively regulates the response to bacteria by modulating FLS2/BAK1 complex formation, suggesting crosstalk...

FLS2是一个典型的富亮氨酸重复受体样激酶(leucine-rich repeat receptor-like kinase, LRR-RLK),在识别细菌鞭毛蛋白(flagellin) 保守N 末端表位(flg22)后,与共受体BAK1 (BRI1-associated kinase 1)异聚化而起始免疫信号[4-7]。 植物细胞含有一套由多个细胞器组成的内膜系统(endomembrane system) early endosome, TGN/EE) 、多囊泡体/液泡前体(multivesicular body/prevacuolar compartment, MVB/ PVC)、液泡等。 植物细胞利用内膜系统完成蛋白质等生物大分子的定向运 …

The plasma membrane-localised FLAGELLIN SENSING 2 (FLS2) receptor is an important component of plant immunity against potentially pathogenic bacteria, acting to recognise the conserved flg22 peptide of flagellin. FLS2 shares the common structure of transmembrane receptor kinases with a receptor-like …

2000年6月1日 · Here, we describe the identification of a new locus, FLS2, by a map-based strategy. The FLS2 gene is ubiquitously expressed and encodes a putative receptor kinase. FLS2 shares structural and functional homologies with known plant resistance genes and with components involved in the innate immune system of mammals and insects.

2024年3月11日 · The receptor-like kinase FLAGELLIN-SENSITIVE 2 (FLS2) functions as a bacterial flagellin receptor localized on the cell membrane of plants. In Arabidopsis, the co-receptor BRI1-ASSOCIATED RECEPTOR KINASE 1 (BAK1) cooperates with FLS2 to detect the flagellin epitope flg22, resulting in formation of a …

2012年10月5日 · FLS2 shares the common structure of transmembrane receptor kinases with a receptor-like ectodomain composed of leucine-rich repeats (LRR) and an active intracellular kinase domain. Upon ligand binding, FLS2 dimerises with the regulatory LRR-receptor kinase BRI1-associated kinase 1, which in turn triggers downstream signalling cascades.

2024年1月10日 · FLS2介导的信号激活与信号传导模型 综上，该研究阐明了水稻OsFLS2介导鞭毛蛋白信号激活与信号转导的分子机制，拓宽了我们对植物受体激酶信号通路的理解。