2021年3月26日 · The strong correlation between type 1 cDC (cDC1) infiltration of human cancers with overall survival in many cancer types suggests the potential use of Flt3L to boost …

In this review, Flt3 is discussed with a particular focus on DCs. We detail the lifecycle of Flt3, from transcription to degradation, and interrogate recent studies as to how this pathway can be …

Flt3L/Flt3 is an essential pathway for DC development and function, although its potential in cancer immunotherapy is not yet clearly established. Herein, we will review the current …

2024年5月1日 · Flt3 is critical for DC development, but it is unclear how Flt3 expression and signaling impacts terminally differentiated cDCs. In this study we investigated Flt3 expression …

2023年12月19日 · FLT3-L-dependent classical dendritic cells (cDCs) recruit anti-tumor and tumor-protecting lymphocytes. We evaluate cancer growth in mice with low, normal, or high levels of …

2023年8月8日 · In this study, using fate mapping models, single-cell RNA sequencing (scRNA-seq), and adoptive transfer, we showed that the FLT3+ CD11c − R2 cells are DC progenitors …

In this review, Flt3 is discussed with a particular focus on DCs. We detail the lifecycle of Flt3, from transcription to degradation, and interrogate recent studies as to how this pathway can be …

2008年5月11日 · Here we report on the function of Flt3 in DC development in the bone marrow and in peripheral lymphoid organs and show that it is an important regulator of homeostatic …

2020年5月18日 · Here, we engineered T cells to secrete the dendritic cell (DC) growth factor Fms-like tyrosine kinase 3 ligand (Flt3L). Flt3L-secreting T cells expanded intratumoral conventional …

2024年8月20日 · In this study, results from single-cell sequencing data analysis revealed a clear relationship between FLT3 + DCs and Regulatory T cells (Tregs) in liver tissue of LT …