FOXL2 (OMIM 605597) is a transcription factor belonging to the forkhead box (FOX) superfamily, characterized by the forkhead box/winged-helix DNA-binding domain. FOXL2 plays an important role in ovarian development and function. [6]

2024年12月25日 · FOXL2 (Forkhead Box L2) is a Protein Coding gene. Diseases associated with FOXL2 include Blepharophimosis, Ptosis, And Epicanthus Inversus and Premature Ovarian Failure 3. Among its related pathways are Transport of the SLBP independent Mature mRNA and Metabolism of proteins.

Govoroun 等 克隆 了鸡FOXL2基因的 开放读码框 （cFOXL2），提出FOXL2在鸟类中是一种卵巢发育的早期控制因子。 Schmidt等进一步证实鼠类中的FOXL2基因对卵巢的维持和颗粒 细胞分化 是必需的。

The FOXL2 (forkhead box L2) gene is located on chromosome 3 and encodes for forkhead box (FOX) family of transcription factors which play a critical role in various biological processes. Germline FOXL2 mutations have been identified in …

2024年3月22日 · We found that FOXL2 regulates more targets postnatally, through interaction with factors regulating primordial follicle formation and steroidogenesis. Deletion of one interactor, ubiquitin-specific protease 7 (Usp7), results in impairment of somatic cell differentiation, germ cell nest breakdown, and ovarian development, leading to sterility.

翼状螺旋/叉头转录因子2(winged-helix/forkhead transcription factor 2, FOXL2)，属于翼状螺旋/叉头转录因子超家族成员。FOXL2基因在脊椎动物胚胎、眼睑、成体卵巢颗粒细胞中异常表达，与卵巢早衰、不孕、不育、卵巢肿瘤等发生、发展具有一定相关性 [1,2] 。

The FOXL2 gene provides instructions for making a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes. On the basis of this role, the FOXL2 protein is called a transcription factor.

2020年4月24日 · FOXL2 ablation enhances Ku recruitment to DSB sites, imbalances DSB repair kinetics by accelerating NHEJ and inhibiting HR, and thus leads to catastrophic genomic events. Our study unveils...

FOXL2 encodes a transcription factor that regulates a wide array of target genes including those involved in sex development, eyelid development, ovarian function and maintenance, genomic integrity as well as cellular pathways such as cell-cycle progression, proliferation, and apoptosis.

Foxl2 is a forkhead transcription factor essential for proper reproductive function in females. Human patients carrying mutations in the FOXL2 gene display blepharophimosis/ptosis/epicanthus inversus syndrome (BPES), an autosomal dominant disease associated with eyelid defects and premature ovarian …