Here, we evaluate FR104, a novel antagonist pegylated anti-CD28 Fab' antibody fragment, in nonhuman primate renal allotransplantation. FR104, in association with low doses of …

2015年2月1日 · Here, we evaluate FR104, a novel antagonist pegylated anti-CD28 Fab’ antibody fragment, in nonhuman primate renal allotransplantation. FR104, in association with low doses …

Here, we describe FR104, a novel humanized pegylated anti-CD28 Fab' antibody fragment presenting a long elimination half-life in monkeys. In vitro, FR104 failed to induce human T cell …

FR104 是 CHO 表达的人源抗体，靶向 CD28。FR104 带有 huIgG2 型重链和 huκ 型轻链，其预测的分子量 (MW) 为 145 kDa。FR104 的同型对照可参考 Human IgG2 kappa, Isotype Control 。

Here, we describe FR104, a novel humanized pegylated anti-CD28 Fab antibody fragment presenting a long elimination half-life in monkeys. In vitro, FR104 failed to induce human T cell …

2014年12月8日 · Here, we evaluate FR104, a novel antagonist pegylated anti‐CD28 Fab' antibody fragment, in nonhuman primate renal allotransplantation. FR104, in association with …

2012年10月1日 · Here, we describe FR104, a novel humanized pegylated anti-CD28 Fab′ antibody fragment presenting a long elimination half-life in monkeys. In vitro, FR104 failed to …

For that purpose, we developed FR104, a monovalent humanized Fab’ antibody fragment CD28 antagonist, pegylated to prolong its half-life. We recently reported that FR104 cannot induce T …

T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular). CD28 is the receptor for …

FR104 is a humanized antibody expressed in CHO cells that targets CD28. FR104 comprises a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. …