FSHR-deficient osteoclasts have reduced nicotinamide adenine dinucleotide (NAD +) levels, impairing osteoclast activity and energy metabolism. Mechanistically, FSH influenced NAD + levels via the CREB/MDH2 axis. Treatment with FSH monoclonal antibodies rescued bone loss in OVX mice and reduced bone marrow NAD + levels.

This study reveals the effects of follicle-stimulating hormone (FSH) on osteoclast energy metabolism. Methods: The Lyz2-Cre-Flox model selectively deletes FSH receptor (FSHR) from osteoclast precursor cells to generate Fshr f/f; Lyz2-Cre (Fshr f/f; Cre) mice.

2023年11月4日 · FSH结合并激活FSH受体（FSHR）发挥生物学效应，FSHR属于七重跨膜G蛋白偶联受体（GPCR）家族，敲除小鼠FSH β亚基或FSHR基因导致显著的生殖障碍。 传统观念认为，FSH仅是一种重要的生殖激素。 但近10年对FSH及其受体深入研究发现，FSHR在性腺外组织如破骨细胞、脂肪细胞和神经细胞均表达，FSH通过FSHR起到调节骨量、脂质代谢和调控认知功能等。 值得关注的是，大量流行病学研究表明，围绝经期和绝经后女性发生糖尿病、代谢综合 …

2021年12月2日 · Follicle-stimulating hormone (FSH) and its target G protein-coupled receptor (FSHR) are essential for reproduction. Recent studies have established that the hypo-glycosylated pituitary FSH glycoform (FSH21/18), is more bioactive in vitro and in vivo than the fully-glycosylated variant (FSH24).

2018年12月17日 · In this study, we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis. First, epidemiological results show that the serum FSH levels are positively...

2023年1月31日 · Follicle stimulating hormone (FSH) is an essential glycoprotein hormone for human reproduction, which functions are mediated by a G protein-coupled receptor, FSHR....

2023年11月1日 · Follicle-stimulating hormone (FSH) is involved in mammalian reproduction via binding to FSH receptor (FSHR). However, several studies have found that FSH and FSHR play...

2025年1月16日 · In this work, we report a functional role for myostatin as an endocrine hormone that directly promotes pituitary follicle-stimulating hormone (FSH) synthesis and thereby ovarian function in mice. Previously, this FSH-stimulating role was attributed to other members of the transforming growth factor–β family, the activins.

2016年1月5日 · Fshb- i Cre mice develop normally, display no ectopic CRE expression in gonads and are fertile. When crossed onto a loxP recombination-mediated red to green color switch reporter mouse genetic background, in vivo CRE recombinase activity is detectable in gonadotropes at more than 95% efficiency and the GFP-tagged gonadotropes readily purified ...

Histological staining and OARSI scores were used to assess the efficacy of AAV-shFSHR injections. Results: We found that FSH down-regulated the expression of ECM-related …