Follicle stimulating hormone (FSH) is a gonadotropin hormone secreted by anterior pituitary gonadotropic cells, is central to reproduction in mammals and its synthesis is regulated by gonadotropin-releasing hormone (GnRH) pulse. Activin enhances biosynthesis and secretion whereas inhibin downregulates FSH synthesis.

The follicle-stimulating hormone receptor or FSH receptor (FSHR) is a transmembrane receptor that interacts with the follicle-stimulating hormone (FSH) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning of FSH.

卵泡刺激素（FSH）是由垂体前叶促性腺激素细胞分泌的促性腺激素，与卵泡刺激素受体（FSHR）结合，刺激卵泡的生成和精子的发生，FSH或FSHR缺乏会导致男性精子减少以及女性不孕和闭经。 随着研究的不断深入，FSH/FSHR信号通路也不断完善，除了经典的环磷酸腺苷依赖的信号通路以外，还有β-抑制蛋白依赖的通路以及其他通路；FSHR存在不同构象之间的平衡，构象的偏向性会影响其信号传导，对于偏向性信号的产生类别也正不断深入研究。 同 …

2023年1月31日 · Follicle stimulating hormone (FSH) is an essential glycoprotein hormone for human reproduction, which functions are mediated by a G protein-coupled receptor, FSHR....

2023年11月4日 · 该研究首次揭示了卵泡刺激素（Follicle-stimulating hormone，FSH）对胰岛素分泌的调控新机制，以及FSH升高是围绝经女性糖尿病易感性的重要诱因。 黄荷凤团队多年来关注FSH在围绝经期疾病中的作用，在该研究中以FSH和FSHR为切入点，从糖代谢主要靶器官胰腺入手，解析了FSH调控胰岛素分泌的机制，以及在绝经期女性糖尿病发病中的作用。 研究团队从mRNA和蛋白水平多层面首次证实了在人和小鼠的胰岛β细胞中表达FSHR。 根据女性不同生 …

促卵泡激素（follicle-stimulating hormone，FSH）是由垂体分泌的一种糖蛋白激素，能够作用于性腺（睾丸或卵巢）组织特定靶细胞上的卵泡刺激素受体（FSHR），从而调控卵泡的成熟和排卵，以及诱导精子的发生。

2018年1月1日 · Follicle-stimulating hormone (FSH) is produced in the pituitary and is essential for reproduction. It specifically binds to a membrane receptor (FSHR) expressed in somatic cells of the gonads. The FSH/FSHR system presents many peculiarities compared to classical G protein-coupled receptors (GPCRs).

2018年1月1日 · FSH is synthesized and released by gonadotropic cells in the anterior pituitary in response to gonadotropin-releasing hormone (GnRH) from the hypothalamus. It consists of two subunits: α-subunit, which is common to other members of GPHs, LH, hCG, and TSH, and a hormone specific β-subunit.

2025年1月8日 · The FSH-FSHR pathway has been considered an essential regulator in reproductive development and fertility. But there has been emerging evidence of FSHR expression in extragonadal organs. This poses new questions and long-term debates regarding the physiological role of the FSH-FSHR, and underscores …

In this review, we describe the most important structural features of the FSHR intimately involved in regulation of FSHR function, including trafficking, dimerization, and oligomerization, ligand binding, agonist-stimulated activation, and signal transduction.