2020年2月1日 · Follitropin epsilon is a recombinant FSH (rFSH) produced in a cell line of the human expression system GlycoExpress (Glycotope, Germany) for application in assisted reproductive technology (ART), in particular for follicle maturation in …

Dose adjustment of follicle-stimulating hormone (FSH) during ovarian stimulation as part of medically-assisted reproduction in clinical studies: a systematic review covering 10 years (2007–2017)

The hypothalamic decapeptide, GnRH, is the gatekeeper of mammalian reproductive development and function. Activation of specific, high-affinity cell surface receptors (GnRH receptors) on gonadotropes by GnRH triggers signal transduction cascades to stimulate the coordinated synthesis and secretion of the pituitary gonadotropins FSH and LH.

2019年6月1日 · FSH glycosylation varies in two functionally important aspects: microheterogeneity, resulting from oligosaccharide structure variation, and macroheterogeneity, arising from partial FSHβ subunit glycosylation. Although advances in mass spectrometry permit extensive characterization of FSH glycan popu …

Conclusions: Follitropin epsilon 75 IU daily results in a similar ovarian response to a standard dose of 150 IU follitropin alfa. This dose could be tested in a phase III trial. Keywords: Dose-finding; Follitropin epsilon; Human glyco-optimized recombinant FSH; Ovarian stimulation; Recombinant FSH. Copyright © 2019 The Authors.

Follicle stimulating hormone (FSH) is a key endocrine regulator of ovarian function. FSH is secreted as two macro-glycosylation variants; partially glycosylated FSH (FSH21/18)...

In this study, endogenous LH con-centrations ranging between <0.6 IU/l and 5 IU/l were not associated with the chance of ongoing pregnancy, whereas serum progesterone concentration on stimulation day 8 and ovarian response (follicles on stimulation day 8/oocytes) appeared to be significant predictors of ongoing pregnancy.

2020年8月8日 · Our results demonstrate that hypo-glycosylated hFSH21 exerts more robust activation of intracellular signals associated with steroidogenesis than fully-glycosylated hFSH24 in primary porcine granulosa cells, and furthers our understanding of the differing bioactivities of FSH glycoforms in the ovary.

Director of the Protein Chemistry Core Laboratory. My laboratory is interested in the structure-function relations of the gonadotropins. These are members of the glycoprotein hormone family, which consists of the three gonadotropins, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and chorionic gonadotropin (CG).

2011年2月7日 · The association between endogenous LH concentrations during ovarian stimulation in a gonadotrophin-releasing hormone (GnRH) antagonist protocol and pregnancy likelihood was examined in a large combined analysis of individualized patient data obtained after treatment with recombinant FSH and a GnRH antagonist prior to IVF/intracytoplasmic sperm ...