ATP binds and inhibits the neurodegeneration-associated ... - Nature
2019年6月20日 · Kang et al investigate by NMR and modeling methods how ATP influences the neurodegeneration–associated protein FUS. They find that ATP binds the RNA-binding RRM …
FUS interacts with ATP synthase beta subunit and induces ... - PNAS
2018年9月24日 · Our biochemical and genetic experiments demonstrate that FUS interacts with the catalytic subunit of mitochondrial ATP synthase (ATP5B), disrupts the formation of ATP …
FUS interacts with ATP synthase beta subunit and induces
Our biochemical and genetic experiments demonstrate that FUS interacts with the catalytic subunit of mitochondrial ATP synthase (ATP5B), disrupts the formation of ATP synthase …
Uncovering the molecular mechanism for dual effect of ATP on …
2022年9月14日 · Here, taking the fused in sarcoma (FUS) solution as an example, we comprehensively reveal the underlying mechanism by which ATP regulates phase separation …
ATP modulates self-perpetuating conformational conversion …
2023年5月1日 · FUS aggregation was facilitated by the high amount of ATP via phase separation, forming more liquid-like droplets that facilitated oligomerization and subsequent conversion to …
ATP binds and inhibits the neurodegeneration-associated
2019年6月20日 · Adenosine triphosphate (ATP) provides energy for cellular processes but has recently been found to act also as a hydrotrope to maintain protein homeostasis. ATP …
揭示 ATP 对 FUS 溶液中相分离双重作用的分子机制,Science …
在这里，我们以融合肉瘤 (fus) 溶液为例，结合半经验量子力学方法、平均场理论和分子模拟，全面揭示了 atp 调节相分离的潜在机制。 在微观层面，ATP 充当二价或三价结合剂；在宏观层 …
生物物理所揭示FUS诱导神经退行性疾病的新机制 - 爱科学
2018年9月26日 · fus靶向线粒体atp合成从而激活uprmt的研究结果，揭示了fus诱导神经退行性疾病的新机制，提示线粒体损伤可能是ftld-fus和als-fus等多种神经退行性疾病的共有机制，阻断线 …
Adenosine Triphosphate: The Primordial Molecule That Controls …
This review summarizes recent NMR results on the LLPS of human FUS, TDP-43, and the viral nucleocapsid (N) protein of SARS-CoV-2, as modulated by ATP and nucleic acids, revealing …
Uncovering the molecular mechanism for dual effect of ATP on …
2022年9月16日 · Recent studies reported that adenosine triphosphate (ATP) could inhibit and enhance the phase separation in prion-like proteins. The molecular mechanism underlying …