2021年2月3日 · MR-guided focused ultrasound (MRgFUS), in combination with intravenous microbubble administration, has been applied for focal temporary BBB opening in patients with...

2020年10月26日 · Stable cavitation of intravascular microbubbles under FUS induces mechanical forces on the blood–brain barrier (BBB) that transiently increase its permeability for drug delivery (part b).

2022年12月1日 · In recent years, focused ultrasound (FUS) in conjunction with gas-filled microbubble contrast agents has emerged as a powerful tool for transiently and non-invasively disrupting the BBB in a targeted and image-guided manner, allowing for localized delivery of drugs, genes, or other therapeutic agents.

2020年10月6日 · Focused ultrasound (FUS) in combination with microbubbles can non-invasively open the BBB in a targeted manner. Bolus intravenous injections of microbubbles are standard...

fus介导的bbb开口的可视化有助于提高安全性，并阐明提高gbm治疗效果的机制。目前，几种成像方法，包括磁共振成像（mri），光声（pa）成像和单光子发射计算机断层扫描（spect）成像，已被用于监测fus诱导的bbb开口。

Focused ultrasound has been shown to disrupt the BBB in a noninvasive, safe, and targeted manner. It is capable of reliably producing a therapeutic window of up to four hours immediately after treatment. The mechanical effects of focused ultrasound, namely cavitation, are thought to be the principle cause behind this BBB disruption.

2025年1月1日 · The technology of focused ultrasound-mediated disruption of the blood-brain barrier (FUS-BBB opening) has now been used in over 20 Phase 1 clinical trials to validate the safety and feasibility of BBB opening for drug delivery in patients with brain tumors and neurodegenerative diseases.

2021年1月31日 · 血脑屏障（blood-brain barrier，BBB）是指在脑微血管系统里，由脑微血管内皮细胞（brain microvascular endothelial cell）、星形胶质细胞足端（astrocytes）、周细胞（pericyte）及脑血管内皮细胞间的紧密连接（tight junctions）和基膜（basal membrane）共同构成的特殊结构 [1]（图1）。 BBB严格控制血液和脑内物质交换，保护中枢神经系统（central nervoussystem，CNS）免受循环毒素和感染细胞的侵袭，维持大脑微环境稳态。 但其不易渗 …

Focused ultrasound (FUS) is one method to transiently increase permeability of the BBB to promote drug delivery to specific brain regions. An introduction to the BBB and a brief overview of the methods which can be used to circumvent the BBB to promote drug delivery is provided.

2024年12月2日 · Abstract: Objective: Targeted blood-brain barrier (BBB) opening using focused ultrasound (FUS) and micro/nanobubbles is a promising method for brain drug delivery. This study aims to explore the feasibility of multiple instance learning (MIL) in accurate and fast prediction of FUS BBB opening outcomes.