Nutrient-sensing nuclear receptors PPARα and FXR control
2017年4月3日 · The nuclear receptors PPARα (encoded by NR1C1) and farnesoid X receptor (FXR, encoded by NR1H4) are activated in the liver in the fasted and fed state, respectively. …
通过脂肪细胞中PPARγ激活的FXR表达促进脂肪生成。,Biochemical …
2020年4月24日 · 在scd基因启动子中发现了fxr反应元件（fxre），并且fxr与scd基因启动子的fxre结合，并且cdca在脂肪细胞中增强了其结合效率。这些结果表明，fxr通过以脂肪细胞中pparγ依 …
过氧化物酶体增殖物激活受体 (PPAR)在肝脏疾病中的作用及潜在 …
摘要: 过氧化物酶体增殖物激活受体(ppar)是细胞核雌激素受体家族成员，参与多种体内生理病理过程，在细胞代谢、炎症及癌症等方面发挥重要作用，目前已知ppar受体分3种亚型，分别为α …
The roles and interaction of FXR and PPARs in the pathogenesis …
2020年9月1日 · FXR and PPARs are mainly involved in nutrient acquisition from the gut and distribution through the liver to peripheral tissues including adipose and muscle. PPARs …
A new perspective on NAFLD: Focusing on the crosstalk between ...
2022年10月1日 · Based on PPARα, dual PPAR and pan-PPAR agonists with moderate potency, balance and fewer side effects have shown greater therapeutic benefit in targeting NAFLD, …
Cell Metabolism | FXR激活可通过胆汁酸依赖方式降低脂质吸收从 …
由于fxr是 胆汁酸代谢 的主要调节剂，因此fxr激活可能通过降低胆汁酸水平和/或改变胆汁酸组成来影响肠道脂质吸收。 通过UPLC-MS/MS 对肝脏、肠道和胆囊中胆汁酸进行定量检测，发 …
Discovery of FXR/PPARγ dual partial agonist - PubMed
2023年5月1日 · Farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR)γ are nuclear receptor 1 superfamily of transcription factors. FXR and PPARγ agonists …
A triple farnesoid X receptor and peroxisome proliferator-activated ...
2020年11月13日 · Aiming to fuse complementary validated anti-NASH strategies in a single molecule, we have designed and systematically optimized a scaffold for triple activation of …
Nutrient-sensing nuclear receptors PPAR α and FXR control …
2017年3月13日 · The nuclear receptors PPARα (encoded by NR1C1) and farnesoid X receptor (FXR, encoded by NR1H4) are activated in the liver in the fasted and fed state, respectively. …
The roles and interaction of FXR and PPARs in the pathogenesis …
Background and study aims: To identify the roles and interaction of farnesoid X receptor (FXR) and peroxisome proliferator activated receptors (PPARs) in Non-alcoholic fatty liver disease …