Farnesoid X receptor overexpression prevents hepatic steatosis …
2024年2月1日 · FXR alleviates oxidative stress and ROS production in palmitic acid-induced hepatic steatosis. Oxidative stress-mediated activation of inflammasome has a significant …
The critical role of FXR is associated with the regulation of …
2021年3月25日 · Here, using farnesoid X receptor (FXR) knockout (KO) mice, we determined whether FXR prevents the progression of AKI to CKD after renal ischemic-reperfusion (such …
Role of farnesoid X receptor in hepatic steatosis in nonalcoholic …
2020年1月1日 · FXR is a ligand-activated nuclear receptor that plays an important role in regulating lipid metabolism. FXR activation represses hepatic lipogenesis via the FXR-SHP …
The multifaceted role of Fragile X-Related Protein 1 (FXR1) in
2024年1月18日 · FXR1 knockdown increased ROS generation and ROS-FXR1-TGF-b-mediated epirubicin sensitivity. siFXR1’s galectin-3/b-catenin signaling suppression inhibited MDR …
FXR activation suppresses ROS production. A, ROS levels in FXR ...
In the present work, we identify a novel role of FXR in antagonizing c-Jun N-terminal kinase (JNK) signaling pathway in liver carcinogenesis by activating SOD3 transcription.
The role of the farnesoid X receptor in kidney health and disease: a ...
2023年2月3日 · FXR activation by agonists has kidney-protective effects against fibrosis, inflammation, apoptosis, ferroptosis, and ROS accumulation and plays roles in lipid and …
FXR overexpression prevents hepatic steatosis through inhibiting …
2024年1月6日 · DCFH–DA staining was adopted to visualize reactive oxidative species (ROS). FXR was distinctly downregulated in liver tissues of patients with steatosis compared to …
Farnesoid X receptor (FXR) agonists induce hepatocellular …
Farnesoid X receptor (FXR) plays an indispensable role in liver homeostasis and has been a promising drug target for hepatic diseases. However, the concerns of undesired biological …
Cell Metabolism | FXR激活可通过胆汁酸依赖方式降低脂质吸收从 …
目前，NALFD/NASH患者的治疗方案非常有限，不过 核受体 法尼醇X受体 (FXR) 激动剂已显示出较好的应用前景。 已有研究表明，FXR激活与肝脏和血浆 甘油三酯 （TAG）水平降低、炎症 …
NASH等代谢疾病热门靶点——FXR受体，激动 or 拮抗 - 脉脉
2022年1月28日 · FXR（法尼醇X受体）是近几年来非酒精性脂肪性肝病（NAFLD）研究的一个热门靶点。 FXR是核受体超家族的成员之一，该受体于1995年由Forman等发现，因其转录活性 …